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The entry | ==HSV-2 gHecto/gL/CHL27-Fab Complex== | ||
<StructureSection load='10ig' size='340' side='right'caption='[[10ig]], [[Resolution|resolution]] 4.33Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[10ig]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_2 Human alphaherpesvirus 2] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=10IG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=10IG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.33Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=10ig FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=10ig OCA], [https://pdbe.org/10ig PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=10ig RCSB], [https://www.ebi.ac.uk/pdbsum/10ig PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=10ig ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GH_HHV2H GH_HHV2H] The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding of gD to one of its receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Human alphaherpesvirus 2]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Gonzalez-Del Pino GL]] | |||
[[Category: Heldwein EE]] | |||
[[Category: Russell HC]] | |||
[[Category: Walsh RM]] | |||
Latest revision as of 08:56, 30 September 2026
HSV-2 gHecto/gL/CHL27-Fab Complex
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