9yip: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 9yip is ON HOLD Authors: Lodowski, D.T., Chapman, P.Q. Description: Crystal structure of human IL-8 in a large unit cell [[Category: Unreleased Str... |
No edit summary |
||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of human IL-8 in a large unit cell== | |||
<StructureSection load='9yip' size='340' side='right'caption='[[9yip]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9yip]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9YIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9YIP FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9yip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9yip OCA], [https://pdbe.org/9yip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9yip RCSB], [https://www.ebi.ac.uk/pdbsum/9yip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9yip ProSAT]</span></td></tr> | ||
[[Category: Chapman | </table> | ||
[[Category: Lodowski | == Function == | ||
[https://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chapman PQ]] | |||
[[Category: Lodowski DT]] | |||
Latest revision as of 09:50, 30 September 2026
Crystal structure of human IL-8 in a large unit cell
| ||||||||||||
