11zu: Difference between revisions
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==Covalent stabilizer compound 7 for the interaction between 14-3-3 sigma and Estrogen receptor-alpha peptide== | |||
<StructureSection load='11zu' size='340' side='right'caption='[[11zu]], [[Resolution|resolution]] 2.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[11zu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=11ZU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=11ZU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | |||
[[ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1DA6:9-[(3,4-dichlorophenyl)methyl]-6-ethenyl-purine'>A1DA6</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | ||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=11zu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=11zu OCA], [https://pdbe.org/11zu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=11zu RCSB], [https://www.ebi.ac.uk/pdbsum/11zu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=11zu ProSAT]</span></td></tr> | ||
[[ | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Knapp MS]] | |||
[[Category: Tang JY]] | |||
Latest revision as of 09:57, 30 September 2026
Covalent stabilizer compound 7 for the interaction between 14-3-3 sigma and Estrogen receptor-alpha peptide
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