34jy: Difference between revisions

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Created page with "'''Unreleased structure''' The entry 34jy is ON HOLD Authors: Bradshaw, W.J., Hafian, S., Guenther, F. Description: IDOL RING domain in complex with PCM-0102246-001 Category: Unreleased Structures Category: Guenther, F Category: Bradshaw, W.J Category: Hafian, S"
 
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'''Unreleased structure'''


The entry 34jy is ON HOLD
==IDOL RING domain in complex with PCM-0102246-001==
 
<StructureSection load='34jy' size='340' side='right'caption='[[34jy]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
Authors: Bradshaw, W.J., Hafian, S., Guenther, F.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[34jy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=34JY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=34JY FirstGlance]. <br>
Description: IDOL RING domain in complex with PCM-0102246-001
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.478&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1KQ5:2-chloranyl-~{N}-(4,6-dimethyl-1,3-benzothiazol-2-yl)ethanamide'>A1KQ5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Guenther, F]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=34jy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=34jy OCA], [https://pdbe.org/34jy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=34jy RCSB], [https://www.ebi.ac.uk/pdbsum/34jy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=34jy ProSAT]</span></td></tr>
[[Category: Bradshaw, W.J]]
</table>
[[Category: Hafian, S]]
== Function ==
[https://www.uniprot.org/uniprot/MYLIP_HUMAN MYLIP_HUMAN] E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.<ref>PMID:10593918</ref> <ref>PMID:14550572</ref> <ref>PMID:12826659</ref> <ref>PMID:19520913</ref> <ref>PMID:20427281</ref> <ref>PMID:22109552</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bradshaw WJ]]
[[Category: Guenther F]]
[[Category: Hafian S]]
Retrieved from "https://proteopedia.org/34jy"