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Green links change the 3D image! 2q66 - Poly(A) polymerase Poly(A) polymerase binds specifically to ATP and adds it the end of a messenger RNA chain. This structure contains an oligo(A) polynucleotide with five nucleotides, an ATP molecule, and a magnesium ion. … In the summary picture, the enzyme is in blue backbone representation, the RNA chain is in yellow, the ATP is in red, the magnesium is in green, and ALA154 is in magenta. Several mechanisms are used to achieve the specificity for ATP. The magnesium is coordinated by ASP100 and ASP102, and the magnesium coordinates with the phosphates of ATP, positioning the nucleotide in the active site. The adenine base is sandwiched between the terminal base of the RNA (in yellow) and VAL234 (in cyan). Read more...

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Hemoglobin - the protein in your blood responsible for oxygen transport HIV-1 protease - a protein made by the HIV virus that is crucial to its infectious capacity Lac repressor - a protein that controls the expression of bacterial enzymes involved in lactose metabolism More...	All PDB entries (over 54,000) have pages <inputbox> type=search width=20 buttonlabel=Go searchbuttonlabel=Search break=yes </inputbox> Go takes you directly to the page if it exists, Search gives you search results More...	2q66 - yeast poly(a)-polymerase, adds poly-A tails to nascent messenger RNAs Hydrogen bonds Morphs - visualizing conformational changes More...

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Read the paper
Proteopedia - a scientific 'wiki' bridging the rift between 3D structure and function of biomacromolecules, Genome Biology 2008, 9:R121 doi:10.1186/gb-2008-9-8-r121

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Proteopedia Page Contributors and Editors (what is this?)

Eran Hodis