Doppel: Difference between revisions

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Doppel (Dpl), named for '''''do'''wnstream '''p'''rion '''p'''rotein like''<ref>1</ref>, is a homolog of the [[prion protein]] (PrP). It is a cell surface glycoprotein.

[[Doppel]] (Dpl), named for '''''do'''wnstream '''p'''rion '''p'''rotein-like''<ref>Moore, R ''et al.'' (1999) Ataxia in Prion Protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein Doppel ''J. Mol. Biol.'' '''292''', 797-817</ref>, is a homolog of the [[prion protein]] (PrP). It is a cell surface glycoprotein.

==Structure of Dpl==

Dpl has the same fold as PrP, with three alpha helices and two short beta strands, ~~however it~~ differs in ~~that~~ the ~~third~~ helix has a ~~significant~~ kink in it and it also contains two disulphide bonds.

Dpl has the same fold as the C-terminal domain [[PrP]], with three alpha helices and two short beta strands<ref>Mo H ''et al.'' (2001) ''Proc. Natl. Acad. Sci. USA'' '''98''',2352-7</ref>. However Dpl differs from [[PrP]] in two important respects: the second helix of Dpl has a pronounced kink in it, and Dpl also contains <scene name='Doppel/Disulfide_bonds/1'>two disulphide bonds</scene>.

~~=References=~~

The structure mutant PrP with the additional disulphide bond was also determined <ref>Zahn R ''et al.'' (2003) NMR structure of a variant human prion protein with two disulfide bridges '' J. Mol. Biol.'' '''326''', 225-34.</ref>

~~Moore ''et al.'' (1999) Ataxia in Prion Protein (~~PrP)-~~deficient Mice is~~

~~Associated~~ with ~~Upregulation of~~ the ~~Novel PrP-like~~

==Related structures==

~~Protein Doppel ''J. Mol. Biol.'' '''292''', 797-817~~

* [[1z65]] Mouse Dpl residues 1-30

* [[1lg4]] Human Dpl residues 24-152

* [[1i17]] Mouse Dpl residues 51-157

* [[1h0l]] Human PrP residues 121-230, with an additional disulphide bond analogous to the homolog [[Doppel]]

==References==

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-Doppel (Dpl), named for '''''do'''wnstream '''p'''rion '''p'''rotein like''<ref>1</ref>, is a homolog of the [[prion protein]] (PrP). It is a cell surface glycoprotein.
+[[Doppel]] (Dpl), named for '''''do'''wnstream '''p'''rion '''p'''rotein-like''<ref>Moore, R ''et al.'' (1999) Ataxia in Prion Protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein Doppel ''J. Mol. Biol.'' '''292''', 797-817</ref>, is a homolog of the [[prion protein]] (PrP). It is a cell surface glycoprotein.
 ==Structure of Dpl==
-{{STRUCTURE_1lg4 |  PDB=1lg4  |  SCENE=  }}
+{{STRUCTURE_1lg4 |  PDB=1lg4  |  SCENE=Doppel/Cartoon/1  }}
-Dpl has the same fold as PrP, with three alpha helices and two short beta strands, however it differs in that the third helix has a significant kink in it and it also contains two disulphide bonds.
+Dpl has the same fold as the C-terminal domain [[PrP]], with three alpha helices and two short beta strands<ref>Mo H ''et al.'' (2001) ''Proc. Natl. Acad. Sci. USA'' '''98''',2352-7</ref>.  However Dpl differs from [[PrP]] in two important respects: the second helix of Dpl has a pronounced kink in it, and Dpl also contains <scene name='Doppel/Disulfide_bonds/1'>two disulphide bonds</scene>.
-=References=
+The structure mutant PrP with the additional disulphide bond was also determined <ref>Zahn R ''et al.'' (2003) NMR structure of a variant human prion protein with two disulfide bridges '' J. Mol. Biol.'' '''326''', 225-34.</ref>
-Moore ''et al.'' (1999) Ataxia in Prion Protein (PrP)-deficient Mice is
-Associated with Upregulation of the Novel PrP-like
+==Related structures==
-Protein Doppel ''J. Mol. Biol.'' '''292''', 797-817
+* [[1z65]] Mouse Dpl residues 1-30
+* [[1lg4]] Human Dpl residues 24-152
+* [[1i17]] Mouse Dpl residues 51-157
+* [[1h0l]] Human PrP residues 121-230, with an additional disulphide bond analogous to the homolog [[Doppel]]
+==References==
+ <references/>