Doppel: Difference between revisions
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Doppel (Dpl), named for '''''do'''wnstream '''p'''rion '''p'''rotein-like''<ref>Moore, R ''et al.'' (1999) Ataxia in Prion Protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein Doppel ''J. Mol. Biol.'' '''292''', 797-817</ref>, is a homolog of the [[prion protein]] (PrP). It is a cell surface glycoprotein. | [[Doppel]] (Dpl), named for '''''do'''wnstream '''p'''rion '''p'''rotein-like''<ref>Moore, R ''et al.'' (1999) Ataxia in Prion Protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein Doppel ''J. Mol. Biol.'' '''292''', 797-817</ref>, is a homolog of the [[prion protein]] (PrP). It is a cell surface glycoprotein. | ||
==Structure of Dpl== | ==Structure of Dpl== | ||
{{STRUCTURE_1lg4 | PDB=1lg4 | SCENE= }} | {{STRUCTURE_1lg4 | PDB=1lg4 | SCENE=Doppel/Cartoon/1 }} | ||
Dpl has the same fold as PrP, with three alpha helices and two short beta strands<ref>Mo H ''et al.'' (2001) ''Proc. Natl. Acad. Sci. USA'' '''98''',2352-7</ref>. | Dpl has the same fold as the C-terminal domain [[PrP]], with three alpha helices and two short beta strands<ref>Mo H ''et al.'' (2001) ''Proc. Natl. Acad. Sci. USA'' '''98''',2352-7</ref>. However Dpl differs from [[PrP]] in two important respects: the second helix of Dpl has a pronounced kink in it, and Dpl also contains <scene name='Doppel/Disulfide_bonds/1'>two disulphide bonds</scene>. | ||
The structure mutant PrP with the additional disulphide bond was also | The structure mutant PrP with the additional disulphide bond was also determined <ref>Zahn R ''et al.'' (2003) NMR structure of a variant human prion protein with two disulfide bridges '' J. Mol. Biol.'' '''326''', 225-34.</ref> | ||
=Related structures= | ==Related structures== | ||
* [[1z65]] Mouse Dpl residues 1-30 | * [[1z65]] Mouse Dpl residues 1-30 | ||
* [[1lg4]] Human Dpl residues 24-152 | * [[1lg4]] Human Dpl residues 24-152 | ||
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=References= | ==References== | ||
</ | <references/> | ||
