Sandbox22: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
Student (talk | contribs)
students
33,923 edits
No edit summary
Student (talk | contribs)
students
33,923 edits
No edit summary
 
(4 intermediate revisions by the same user not shown)
Line 3: Line 3:
==Glucokinase==
==Glucokinase==


This enzyme facilitates phosphorylation of glucose to glucose-6-phosphate. In humans and most other vertebrates glucokinase is used in teh liver, the pancreas, the gut and brain. It plays an important role in regulating carbohydrate metabolism, triggering shifts in the cell in response to glucose level: glucokinase is a sort of a glucose sensor. It only phosphorylates glucose if its concetnration is high enough. The structure of glucokinase reveals an allosteric site through which small molecules may modulate the kinetic properties of the enzyme; a property that is the basis for using the enzyme when treating type 2 diabetes.
The enzyme glucokinase facilitates phosphorylation of glucose to glucose-6-phosphate. In humans and most other vertebrates glucokinase is used in the liver, the pancreas, the gut and brain. It plays an important role in regulating carbohydrate metabolism, triggering shifts in the cell in response to glucose level: glucokinase is a sort of a glucose sensor. It only phosphorylates glucose if its concetnration is high enough. The structure of glucokinase reveals an allosteric site through which small molecules may modulate the kinetic properties of the enzyme; a property that is the basis for the enzyme use in type 2 diabetes treatment.


===Structure==={{STRUCTURE_1v4s|  PDB=1v4s  |  SCENE=  }}  
===Structure==={{STRUCTURE_1v4s|  PDB=1v4s  |  SCENE=  }}  
The glucokinase has 18 <scene name='Sandbox22/Alpha_helices/1'>alpha helices</scene> (unless we counted wrong), 13 <scene name='Sandbox22/Beta_sheets/5'>beta sheets</scene> (this one is for sure), and 3 <scene name='Sandbox22/Ligands/1'>ligands</scene>: a sodium ion, 2 amino-4-fluoro-5-[(1-methyl-1h-amidazol-2-yl)sulfanyl]-n-(1,3-thiazol-2-yl)benzamide or MRK in short, and last a sugar (alpha-d-glucose) or simply GLC.
The glucokinase has 18 <scene name='Sandbox22/Alpha_helices/1'>alpha helices</scene> (unless we counted wrong), 13 <scene name='Sandbox22/Beta_sheets/5'>beta sheets</scene> (this one is for sure), and 3 <scene name='Sandbox22/Ligands/1'>ligands</scene>: a <scene name='Sandbox22/Sodium_ion/1'>sodium ion</scene>, <scene name='Sandbox22/Glc/1'>T2 amino-4-fluoro-5-[(1-methyl-1h-amidazol-2-yl)sulfanyl]-n-(1,3-thiazol-2-yl)benzamide</scene>
amide or MRK in short, and last a sugar (alpha-d-glucose) or simply GLC.
 
Purple denotes all the <scene name='Sandbox22/Polar/2'>polar</scene> sections of the protein: the hydrophillic areas that dominate the outer surface which comes in contact with aqueous environments. In this view we can see very neatly how the beta sheets alternate in polarity in a 'zigzag manner, and how the alpha helices are roughly 2-3 polar (while the inner protein is obviously hydrophobic). The
<scene name='Sandbox22/Spacefill/2'>spacefill representation</scene>, in particular, shows how the surface is dominantly hydrophillic.


===Reference===
===Reference===
Line 15: Line 19:


--Tinuke (Abike etc. etc. etc.) Adeyemi and Niva Ran
--Tinuke (Abike etc. etc. etc.) Adeyemi and Niva Ran
and Matt Joseph Rozin and Gregory Mark Su (because they're so darn cute.)
Retrieved from "https://proteopedia.org/Sandbox22"