1xcs: Difference between revisions

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New page: left|200px<br /><applet load="1xcs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1xcs, resolution 1.40Å" /> '''structure of oligonu...
 
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[[Image:1xcs.gif|left|200px]]<br /><applet load="1xcs" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1xcs, resolution 1.40&Aring;" />
'''structure of oligonucleotide/drug complex'''<br />


==Overview==
==structure of oligonucleotide/drug complex==
The crystal structures of the hexamer duplex d(CGTACG)(2) complexed with, the intercalating anthraquinone derivative, 1,5-bis[3-(diethylamino)propionamido]anthracene-9,10-dione and the, acridine derivative 9-acridinyl tetralysine have been solved at 2.0- and, 1.4-A resolution, respectively. In both cases, the drugs adopt multiple, orientations within a large DNA cavity constituted by two groups of four, approximately coplanar bases. Cations play a pivotal role in the crystal, structure. Both complexes crystallise in the presence of Co(2+), Ba(2+), and Na(+) ions. They reveal at least two different types of coordination, environments: (1) specific sites for Co(2+) interacting with N7 of, guanine; (2) a central ionic site formed by four phosphate groups, which, can be occupied by different ions. One more ionic site that is not always, occupied by ions is also visible in the electron density map. All of them, play a role in the crystal structure.
<StructureSection load='1xcs' size='340' side='right'caption='[[1xcs]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1xcs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XCS FirstGlance]. <br>
1XCS is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with CO, BA and A4L as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1XCS OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A4L:9-[(5-(ACETYLAMINO)-6-{[(1S,4R)-8-AMINO-4-[((2R)-6-AMINO-2-{2-[(1S)-5-AMINO-1-FORMYLPENTYL]HYDRAZINO}HEXANOYL)AMINO]-1-(4-AMINOBUTYL)-2,3-DIOXOOCTYL]AMINO}-6-OXOHEXYL)AMINO]-6-CHLORO-2-METHOXYACRIDINIUM'>A4L</scene>, <scene name='pdbligand=BA:BARIUM+ION'>BA</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xcs OCA], [https://pdbe.org/1xcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xcs RCSB], [https://www.ebi.ac.uk/pdbsum/1xcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xcs ProSAT]</span></td></tr>
Variable role of ions in two drug intercalation complexes of DNA., Valls N, Steiner RA, Wright G, Murshudov GN, Subirana JA, J Biol Inorg Chem. 2005 Aug;10(5):476-82. Epub 2005 Sep 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15926069 15926069]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Murshudov, G.N.]]
</StructureSection>
[[Category: Steiner, R.A.]]
[[Category: Large Structures]]
[[Category: Subirana, J.A.]]
[[Category: Murshudov GN]]
[[Category: Valls, N.]]
[[Category: Steiner RA]]
[[Category: Wright, G.]]
[[Category: Subirana JA]]
[[Category: A4L]]
[[Category: Valls N]]
[[Category: BA]]
[[Category: Wright G]]
[[Category: CO]]
[[Category: co2+]]
[[Category: double helix]]
[[Category: drug-dna complex]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 01:52:22 2007''

Latest revision as of 08:49, 14 February 2024

structure of oligonucleotide/drug complex

1xcs, resolution 1.40Å

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