3fsn: Difference between revisions

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{{Seed}}
[[Image:3fsn.jpg|left|200px]]


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==Crystal structure of RPE65 at 2.14 angstrom resolution==
The line below this paragraph, containing "STRUCTURE_3fsn", creates the "Structure Box" on the page.
<StructureSection load='3fsn' size='340' side='right'caption='[[3fsn]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3fsn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The March 2012 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Rhodopsin''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2012_3 10.2210/rcsb_pdb/mom_2012_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FSN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FSN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
{{STRUCTURE_3fsn| PDB=3fsn |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fsn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fsn OCA], [https://pdbe.org/3fsn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fsn RCSB], [https://www.ebi.ac.uk/pdbsum/3fsn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fsn ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RPE65_BOVIN RPE65_BOVIN] Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association.<ref>PMID:16096063</ref> <ref>PMID:19805034</ref> <ref>PMID:20100834</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fs/3fsn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fsn ConSurf].
<div style="clear:both"></div>


===Crystal structure of RPE65 at 2.14 angstrom resolution===
==See Also==
 
*[[Retinoid isomerohydrolase|Retinoid isomerohydrolase]]
 
== References ==
==About this Structure==
<references/>
3FSN is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FSN OCA].
__TOC__
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Retinol isomerase]]
[[Category: Large Structures]]
[[Category: Kiser, P D.]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Lodowski, D T.]]
[[Category: Rhodopsin]]
[[Category: Palczewski, K]]
[[Category: Kiser PD]]
[[Category: 7-bladed beta-propeller]]
[[Category: Lodowski DT]]
[[Category: Cell membrane]]
[[Category: Palczewski K]]
[[Category: Cytoplasm]]
[[Category: Isomerase]]
[[Category: Isomerohydrolase]]
[[Category: Lipoprotein]]
[[Category: Membrane]]
[[Category: Palmitate]]
[[Category: Palmitoylation]]
[[Category: Sensory transduction]]
[[Category: Vision]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 30 09:27:01 2009''
Retrieved from "https://proteopedia.org/3fsn"