2kmj: Difference between revisions
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< | ==High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry== | ||
<StructureSection load='2kmj' size='340' side='right'caption='[[2kmj]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2kmj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_2 Human immunodeficiency virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KMJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> | |||
-- | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZUK:5-PYRIMIDIN-2-YL-D-NORVALINE'>ZUK</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmj OCA], [https://pdbe.org/2kmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kmj RCSB], [https://www.ebi.ac.uk/pdbsum/2kmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kmj ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Target TAR by NMR: Tripeptides containing arginines as terminal residues and non-natural amino acids as central residues are good leads for drug design to target the HIV trans-activation response element (TAR). The structural characterization of the RNA-ligand complex by NMR spectroscopy reveals two specific binding sites that are located at bulge residue U23 and around the pyrimidine-stretch U40-C41-U42 directly adjacent to the bulge. | |||
Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.,Ferner J, Suhartono M, Breitung S, Jonker HR, Hennig M, Wohnert J, Gobel M, Schwalbe H Chembiochem. 2009 Jun 15;10(9):1490-4. PMID:19444830<ref>PMID:19444830</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2kmj" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
== | |||
< | |||
[[Category: Human immunodeficiency virus 2]] | [[Category: Human immunodeficiency virus 2]] | ||
[[Category: Breitung | [[Category: Large Structures]] | ||
[[Category: Ferner | [[Category: Breitung S]] | ||
[[Category: Goebel | [[Category: Ferner J]] | ||
[[Category: Hennig | [[Category: Goebel M]] | ||
[[Category: Jonker | [[Category: Hennig M]] | ||
[[Category: Schwalbe | [[Category: Jonker HRA]] | ||
[[Category: Suhartono | [[Category: Schwalbe H]] | ||
[[Category: Woehnert | [[Category: Suhartono M]] | ||
[[Category: Woehnert J]] | |||
Latest revision as of 06:09, 27 November 2024
High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry
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