2koe: Difference between revisions

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{{Seed}}
[[Image:2koe.jpg|left|200px]]


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==Human cannabinoid receptor 1 - helix 7/8 peptide==
The line below this paragraph, containing "STRUCTURE_2koe", creates the "Structure Box" on the page.
<StructureSection load='2koe' size='340' side='right'caption='[[2koe]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2koe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KOE FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2koe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2koe OCA], [https://pdbe.org/2koe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2koe RCSB], [https://www.ebi.ac.uk/pdbsum/2koe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2koe ProSAT]</span></td></tr>
{{STRUCTURE_2koe|  PDB=2koe  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/CNR1_HUMAN CNR1_HUMAN] Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.<ref>PMID:15620723</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ko/2koe_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2koe ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We report the NMR solution structure of a synthetic 40-mer (T(377)-E(416)) that encompasses human cannabinoid receptor-1 (hCB1) transmembrane helix 7 (TMH7) and helix 8 (H8) [hCB1(TMH7/H8)] in 30% trifluoroethanol/H(2)O. Structural features include, from the peptide's amino terminus, a hydrophobic alpha-helix (TMH7); a loop-like, 11 residue segment featuring a pronounced Pro-kink within the conserved NPxxY motif; a short amphipathic alpha-helix (H8) orthogonal to TMH7 with cationic and hydrophobic amino-acid clusters; and an unstructured C-terminal end. The hCB1(TMH7/H8) NMR solution structure suggests multiple electrostatic amino-acid interactions, including an intrahelical H8 salt bridge and a hydrogen-bond network involving the peptide's loop-like region. Potential cation-pi and cation-phenolic OH interactions between Y(397) in the TMH7 NPxxY motif and R(405) in H8 are identified as candidate structural forces promoting interhelical microdomain formation. This microdomain may function as a flexible molecular hinge during ligand-induced hCB1 conformer transitions.


===Human cannabinoid receptor 1 - helix 7/8 peptide===
NMR solution structure of human cannabinoid receptor-1 helix 7/8 peptide: candidate electrostatic interactions and microdomain formation.,Tyukhtenko S, Tiburu EK, Deshmukh L, Vinogradova O, Janero DR, Makriyannis A Biochem Biophys Res Commun. 2009 Dec 18;390(3):441-6. Epub 2009 Sep 18. PMID:19766594<ref>PMID:19766594</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_19766594}}, adds the Publication Abstract to the page
<div class="pdbe-citations 2koe" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19766594 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_19766594}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Homo sapiens]]
2KOE is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KOE OCA].
[[Category: Large Structures]]
 
[[Category: Deshmukh L]]
==Reference==
[[Category: Janero D]]
<ref group="xtra">PMID:19766594</ref><references group="xtra"/>
[[Category: Makriyannis A]]
[[Category: Deshmukh, L.]]
[[Category: Tiburu E]]
[[Category: Janero, D.]]
[[Category: Tyukhtenko S]]
[[Category: Makriyannis, A.]]
[[Category: Vinogradova O]]
[[Category: Tiburu, E.]]
[[Category: Tyukhtenko, S.]]
[[Category: Vinogradova, O.]]
[[Category: Gpcr]]
[[Category: Hcb1]]
[[Category: Membrane protein]]
[[Category: Signaling protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct  7 13:53:22 2009''

Latest revision as of 09:40, 22 May 2024

Human cannabinoid receptor 1 - helix 7/8 peptide

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