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New page: left|200px<br /><applet load="1kxk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kxk, resolution 3.0Å" /> '''Crystal Structure of ...
 
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[[Image:1kxk.gif|left|200px]]<br /><applet load="1kxk" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1kxk, resolution 3.0&Aring;" />
'''Crystal Structure of a RNA Molecule Containing Domain 5 and 6 of the Yeast ai5g Group II Self-splicing Intron'''<br />


==Overview==
==Crystal Structure of a RNA Molecule Containing Domain 5 and 6 of the Yeast ai5g Group II Self-splicing Intron==
Group II self-splicing introns catalyze autoexcision from precursor RNA, transcripts by a mechanism strikingly similar to that of the spliceosome, an RNA-protein assembly responsible for splicing together the, protein-coding parts of most eukaryotic pre-mRNAs. Splicing in both cases, initiates via nucleophilic attack at the 5' splice site by the 2' OH of a, conserved intron adenosine residue, creating a branched (lariat), intermediate. Here, we describe the crystal structure at 3.0 A resolution, of a 70-nucleotide RNA containing the catalytically essential domains 5, and 6 of the yeast ai5gamma group II self-splicing intron, revealing an, unexpected two-nucleotide bulged structure around the branch-point, adenosine in domain 6.
<StructureSection load='1kxk' size='340' side='right'caption='[[1kxk]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1kxk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KXK FirstGlance]. <br>
1KXK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KXK OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kxk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kxk OCA], [https://pdbe.org/1kxk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kxk RCSB], [https://www.ebi.ac.uk/pdbsum/1kxk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kxk ProSAT]</span></td></tr>
Structural insights into group II intron catalysis and branch-site selection., Zhang L, Doudna JA, Science. 2002 Mar 15;295(5562):2084-8. Epub 2002 Feb 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11859154 11859154]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Doudna, J.A.]]
</StructureSection>
[[Category: Zhang, L.]]
[[Category: Large Structures]]
[[Category: MG]]
[[Category: Saccharomyces cerevisiae]]
[[Category: double helix]]
[[Category: Doudna JA]]
[[Category: tetraloop]]
[[Category: Zhang L]]
[[Category: tetraloop receptor]]
[[Category: two-nucleotide bulge]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:08:23 2007''

Latest revision as of 07:28, 14 February 2024

Crystal Structure of a RNA Molecule Containing Domain 5 and 6 of the Yeast ai5g Group II Self-splicing Intron

1kxk, resolution 3.00Å

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