3hvj: Difference between revisions

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{{Seed}}
[[Image:3hvj.jpg|left|200px]]


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==Rat catechol O-methyltransferase in complex with a catechol-type, N6-propyladenine-containing bisubstrate inhibitor==
The line below this paragraph, containing "STRUCTURE_3hvj", creates the "Structure Box" on the page.
<StructureSection load='3hvj' size='340' side='right'caption='[[3hvj]], [[Resolution|resolution]] 1.79&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3hvj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HVJ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=705:N-[(E)-3-[(2R,3S,4R,5R)-3,4-DIHYDROXY-5-(6-PROPYLAMINOPURIN-9-YL)OXOLAN-2-YL]PROP-2-ENYL]-5-(4-FLUOROPHENYL)-2,3-DIHYDROXY-BENZAMIDE'>705</scene>, <scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_3hvj| PDB=3hvj |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hvj OCA], [https://pdbe.org/3hvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hvj RCSB], [https://www.ebi.ac.uk/pdbsum/3hvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hvj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hv/3hvj_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hvj ConSurf].
<div style="clear:both"></div>


===Rat catechol O-methyltransferase in complex with a bisubstrate inhibitor===
==See Also==
 
*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
3HVJ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HVJ OCA].
[[Category: Large Structures]]
[[Category: Catechol O-methyltransferase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Benz, J.]]
[[Category: Benz J]]
[[Category: Ehler, A.]]
[[Category: Ehler A]]
[[Category: Rudolph, M G.]]
[[Category: Rudolph MG]]
[[Category: Schlatter, D.]]
[[Category: Schlatter D]]
[[Category: Stihle, M.]]
[[Category: Stihle M]]
[[Category: Alternative initiation]]
[[Category: Catecholamine metabolism]]
[[Category: Cell membrane]]
[[Category: Cytoplasm]]
[[Category: Magnesium]]
[[Category: Membrane]]
[[Category: Metal-binding]]
[[Category: Methyltransferase]]
[[Category: Neurotransmitter degradation]]
[[Category: Phosphoprotein]]
[[Category: S-adenosyl-l-methionine]]
[[Category: Signal-anchor]]
[[Category: Transferase]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 14 10:35:06 2009''
Retrieved from "https://proteopedia.org/3hvj"