1l1h: Difference between revisions
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New page: left|200px<br /><applet load="1l1h" size="450" color="white" frame="true" align="right" spinBox="true" caption="1l1h, resolution 1.75Å" /> '''Crystal Structure of... |
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== | ==Crystal Structure of the Quadruplex DNA-Drug Complex== | ||
Stabilisation of G-quadruplex structures formed from telomeric DNA, by | <StructureSection load='1l1h' size='340' side='right'caption='[[1l1h]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1l1h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L1H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PYN:3-PYRROLIDIN-1-YL-N-[6-(3-PYRROLIDIN-1-YL-PROPIONYLAMINO)-ACRIDIN-3-YL]-PROPIONAMIDE'>PYN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l1h OCA], [https://pdbe.org/1l1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l1h RCSB], [https://www.ebi.ac.uk/pdbsum/1l1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l1h ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Stabilisation of G-quadruplex structures formed from telomeric DNA, by means of quadruplex-selective ligands, is a means of inhibiting the telomerase enzyme from catalysing the synthesis of telomeric DNA repeats. In order to understand the molecular basis of ligand-quadruplex recognition, the crystal structure has been determined of such a complex, at 1.75A resolution. This complex is between a dimeric antiparallel G-quadruplex formed from the Oxytricha nova telomeric DNA sequence d(GGGGTTTTGGGG), and a di-substituted aminoalkylamido acridine compound. The structure shows that the acridine moiety is bound at one end of the stack of G-quartets, within one of the thymine loops. It is held in place by a combination of stacking interactions and specific hydrogen bonds with thymine bases. The stability of the ligand in this binding site has been confirmed by a 2ns molecular dynamics simulation. | |||
Structure of a G-quadruplex-ligand complex.,Haider SM, Parkinson GN, Neidle S J Mol Biol. 2003 Feb 7;326(1):117-25. PMID:12547195<ref>PMID:12547195</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
[[Category: | <div class="pdbe-citations 1l1h" style="background-color:#fffaf0;"></div> | ||
[[Category: Haider | == References == | ||
[[Category: Neidle | <references/> | ||
[[Category: Parkinson | __TOC__ | ||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Haider SM]] | |||
[[Category: Neidle S]] | |||
[[Category: Parkinson GN]] | |||
Latest revision as of 09:08, 16 August 2023
Crystal Structure of the Quadruplex DNA-Drug Complex
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