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New page: left|200px<br /><applet load="1d32" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d32, resolution 1.700Å" /> '''DRUG-INDUCED DNA RE...
 
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[[Image:1d32.jpg|left|200px]]<br /><applet load="1d32" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1d32, resolution 1.700&Aring;" />
'''DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX'''<br />


==Overview==
==DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX==
Ditercalinium is a synthetic anticancer drug that binds to DNA by, bis-intercalation and activates DNA repair processes. In prokaryotes, noncovalent DNA-ditercalinium complexes are incorrectly recognized by the, uvrABC repair system as covalent lesions on DNA. In eukaryotes, mitochondrial DNA is degraded by excess and futile DNA repair. Using x-ray, crystallography, we have determined, to 1.7 A resolution, the, three-dimensional structure of a complex of ditercalinium bound to the, double-stranded DNA fragment [d(CGCG)]2. The DNA in the complex with, ditercalinium is kinked (by 15 degrees) and severely unwound (by 36, degrees) with exceptionally wide major and minor grooves. Recognition of, the DNA-ditercalinium complex by uvrABC in prokaryotes, and by, mitochondrial DNA repair systems in eukaryotes, might be related to, drug-induced distortion of the DNA helix.
<StructureSection load='1d32' size='340' side='right'caption='[[1d32]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1d32]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D32 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D32 FirstGlance]. <br>
1D32 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with DIT as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D32 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIT:DITERCALINIUM'>DIT</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d32 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d32 OCA], [https://pdbe.org/1d32 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d32 RCSB], [https://www.ebi.ac.uk/pdbsum/1d32 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d32 ProSAT]</span></td></tr>
Drug-induced DNA repair: X-ray structure of a DNA-ditercalinium complex., Gao Q, Williams LD, Egli M, Rabinovich D, Chen SL, Quigley GJ, Rich A, Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2422-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2006181 2006181]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Chen, S.L.]]
</StructureSection>
[[Category: Egli, M.]]
[[Category: Large Structures]]
[[Category: Gao, Q.]]
[[Category: Chen S-L]]
[[Category: Quigley, G.J.]]
[[Category: Egli M]]
[[Category: Rabinovich, D.]]
[[Category: Gao Q]]
[[Category: Rich, A.]]
[[Category: Quigley GJ]]
[[Category: Williams, L.D.]]
[[Category: Rabinovich D]]
[[Category: DIT]]
[[Category: Rich A]]
[[Category: complexed with drug]]
[[Category: Williams LD]]
[[Category: double helix]]
[[Category: right handed dna]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:21:50 2007''

Latest revision as of 06:48, 7 February 2024

DRUG-INDUCED DNA REPAIR: X-RAY STRUCTURE OF A DNA-DITERCALINIUM COMPLEX

1d32, resolution 1.70Å

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