1d65: Difference between revisions

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New page: left|200px<br /><applet load="1d65" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d65, resolution 2.200Å" /> '''MOLECULAR STRUCTURE...
 
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[[Image:1d65.gif|left|200px]]<br /><applet load="1d65" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1d65, resolution 2.200&Aring;" />
'''MOLECULAR STRUCTURE OF THE B-DNA DODECAMER D(CGCAAATTTGCG)2; AN EXAMINATION OF PROPELLER TWIST AND MINOR-GROOVE WATER STRUCTURE AT 2.2 ANGSTROMS RESOLUTION'''<br />


==Overview==
==MOLECULAR STRUCTURE OF THE B-DNA DODECAMER D(CGCAAATTTGCG)2; AN EXAMINATION OF PROPELLER TWIST AND MINOR-GROOVE WATER STRUCTURE AT 2.2 ANGSTROMS RESOLUTION==
The crystal structure of the dodecanucleotide duplex d(CGCAAATTTGCG)2 has, been solved to 2.2 A resolution and refined to an R-factor of 18.1% with, the inclusion of 71 water molecules. The structure shows propeller twists, of up to -20 degrees for the A.T base-pairs, although there is probably, only one (weak) three-centre hydrogen bond in the six base-pair AT narrow, minor-groove region. An extensive ribbon of hydration has been located in, this groove that has features distinctive from the classic "spine of, hydration". Solvation around phosphate groups is described, with several, instances of water molecules bridging between phosphates.
<StructureSection load='1d65' size='340' side='right'caption='[[1d65]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1d65]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D65 FirstGlance]. <br>
1D65 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D65 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d65 OCA], [https://pdbe.org/1d65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d65 RCSB], [https://www.ebi.ac.uk/pdbsum/1d65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d65 ProSAT]</span></td></tr>
==Reference==
</table>
Molecular structure of the B-DNA dodecamer d(CGCAAATTTGCG)2. An examination of propeller twist and minor-groove water structure at 2.2 A resolution., Edwards KJ, Brown DG, Spink N, Skelly JV, Neidle S, J Mol Biol. 1992 Aug 20;226(4):1161-73. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1518049 1518049]
__TOC__
[[Category: Protein complex]]
</StructureSection>
[[Category: Brown, D.G.]]
[[Category: Large Structures]]
[[Category: Edwards, K.J.]]
[[Category: Brown DG]]
[[Category: Neidle, S.]]
[[Category: Edwards KJ]]
[[Category: Spink, N.]]
[[Category: Neidle S]]
[[Category: b-dna]]
[[Category: Spink N]]
[[Category: double helix]]
 
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