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New page: left|200px<br /><applet load="1d91" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d91, resolution 2.100Å" /> '''G.T BASE PAIRS IN A...
 
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[[Image:1d91.gif|left|200px]]<br /><applet load="1d91" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1d91, resolution 2.100&Aring;" />
'''G.T BASE PAIRS IN A DNA HELIX. THE CRYSTAL STRUCTURE OF D(G-G-G-G-T-C-C-C)'''<br />


==Overview==
==G.T BASE PAIRS IN A DNA HELIX. THE CRYSTAL STRUCTURE OF D(G-G-G-G-T-C-C-C)==
The synthetic deoxyoctanucleotide d(G-G-G-G-T-C-C-C) crystallizes as an, A-type DNA double helix containing two adjacent G . T base-pair, mismatches. The structure has been refined to an R-factor of 14% at 2.1 A, resolution with 104 solvent molecules located. The two G . T mismatches, adopt the "wobble" form of base-pairing. The mismatched bases are linked, by a network of water molecules interacting with the exposed functional, groups in both the major and minor grooves. The presence of two mispaired, bases in the octamer has surprisingly little effect on the global, structure of the helix or the backbone and glycosidic torsional angles., Base stacking around the mismatch is perturbed, but the central G-T step, shows particularly good base overlap, which may contribute to the, relatively high stability of this oligomer.
<StructureSection load='1d91' size='340' side='right'caption='[[1d91]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1d91]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D91 FirstGlance]. <br>
1D91 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D91 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d91 OCA], [https://pdbe.org/1d91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d91 RCSB], [https://www.ebi.ac.uk/pdbsum/1d91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d91 ProSAT]</span></td></tr>
==Reference==
</table>
G . T base-pairs in a DNA helix: the crystal structure of d(G-G-G-G-T-C-C-C)., Kneale G, Brown T, Kennard O, Rabinovich D, J Mol Biol. 1985 Dec 20;186(4):805-14. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=4093986 4093986]
__TOC__
[[Category: Protein complex]]
</StructureSection>
[[Category: Brown, T.]]
[[Category: Large Structures]]
[[Category: Kennard, O.]]
[[Category: Brown T]]
[[Category: Kneale, G.]]
[[Category: Kennard O]]
[[Category: Rabinovich, D.]]
[[Category: Kneale G]]
[[Category: a-dna]]
[[Category: Rabinovich D]]
[[Category: double helix]]
[[Category: mismatched]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:46:59 2007''

Latest revision as of 06:50, 7 February 2024

G.T BASE PAIRS IN A DNA HELIX. THE CRYSTAL STRUCTURE OF D(G-G-G-G-T-C-C-C)

1d91, resolution 2.10Å

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