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New page: left|200px<br /><applet load="1d93" size="450" color="white" frame="true" align="right" spinBox="true" caption="1d93, resolution 2.150Å" /> '''STRUCTURAL VARIATIO...
 
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[[Image:1d93.gif|left|200px]]<br /><applet load="1d93" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1d93, resolution 2.150&Aring;" />
'''STRUCTURAL VARIATION IN D(CTCTAGAG). IMPLICATIONS FOR PROTEIN-DNA INTERACTIONS'''<br />


==Overview==
==STRUCTURAL VARIATION IN D(CTCTAGAG). IMPLICATIONS FOR PROTEIN-DNA INTERACTIONS==
Single-crystal X-ray diffraction techniques have been used to characterize, the structure of the self-complementary DNA oligomer d(CTCTAGAG). The, structure was refined to an R factor of 14.7% using data to 2.15-A, resolution. The tetragonal unit cell, space group P4(3)2(1)2, has, dimensions a = 42.53 and c = 24.33 A. The asymmetric unit consists of a, single strand or four base pairs. Two strands, related by a, crystallographic dyad axis, coil about each other to form a right-handed, duplex. This octamer duplex has a mean helix rotation of 32 degrees, 11.3, base pairs per turn, an average rise of 3.1 A, C3'-endo furanose, conformations, a shallow minor groove, and a deep major groove. Such, averaged parameters suggest classification of the octamer as a member of, the A-DNA family. However, the global parameters tend to mask variations, in conformational parameters observed at the level of the base pairs. In, particular, the central TpA (= TpA) step displays extensive interstrand, purine-purine overlap and an unusual sugar-phosphate backbone, conformation. These structural features may be directly related to certain, sequence-specific protein-DNA interactions involving nucleases and, repressors.
<StructureSection load='1d93' size='340' side='right'caption='[[1d93]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1d93]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D93 FirstGlance]. <br>
1D93 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1D93 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d93 OCA], [https://pdbe.org/1d93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d93 RCSB], [https://www.ebi.ac.uk/pdbsum/1d93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d93 ProSAT]</span></td></tr>
==Reference==
</table>
Structural variation in d(CTCTAGAG). Implications for protein-DNA interactions., Hunter WN, D'Estaintot BL, Kennard O, Biochemistry. 1989 Mar 21;28(6):2444-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2730875 2730875]
__TOC__
[[Category: Protein complex]]
</StructureSection>
[[Category: Estaintot, B.Langlois.D.]]
[[Category: Large Structures]]
[[Category: Hunter, W.N.]]
[[Category: Hunter WN]]
[[Category: Kennard, O.]]
[[Category: Kennard O]]
[[Category: a-dna]]
[[Category: Langlois D'Estaintot B]]
[[Category: double helix]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:47:34 2007''

Latest revision as of 06:50, 7 February 2024

STRUCTURAL VARIATION IN D(CTCTAGAG). IMPLICATIONS FOR PROTEIN-DNA INTERACTIONS

1d93, resolution 2.15Å

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