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New page: left|200px<br /><applet load="1da2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1da2, resolution 1.700Å" /> '''MOLECULAR AND CRYST...
 
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[[Image:1da2.gif|left|200px]]<br /><applet load="1da2" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1da2, resolution 1.700&Aring;" />
'''MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA'''<br />


==Overview==
==MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA==
The base analogue N4-methoxycytosine (mo4C) is ambivalent in its, hydrogen-bonding potential, since it forms stable base-pairs with both, adenine and guanine in oligomer duplexes. To investigate the base-pair, geometry, the structure of d(CGCGmo4CG) has been determined by, single-crystal X-ray diffraction techniques. The d(CGCGmo4CG)2, crystallized in a left-handed double helical structure (Z-type)., Refinement using 2559 reflections between 10 and 1.7 A converged with a, final R = 0.181 (Rw = 0.130) including 68 solvent molecules. The, orthorhombic crystals are in the space group P2(1)2(1)2(1), with cell, dimensions a = 18.17 A, b = 30.36 A, c = 43.93 A. The mo4C.G base-pair is, of the wobble type, with mo4C in the imino form, and the methoxy group in, the syn configuration.
<StructureSection load='1da2' size='340' side='right'caption='[[1da2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1da2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DA2 FirstGlance]. <br>
1DA2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DA2 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C45:N4-METHOXY-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>C45</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1da2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1da2 OCA], [https://pdbe.org/1da2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1da2 RCSB], [https://www.ebi.ac.uk/pdbsum/1da2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1da2 ProSAT]</span></td></tr>
Molecular and crystal structure of d(CGCGmo4CG): N4-methoxycytosine.guanine base-pairs in Z-DNA., Van Meervelt L, Moore MH, Lin PK, Brown DM, Kennard O, J Mol Biol. 1990 Dec 5;216(3):773-81. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2258939 2258939]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Brown, D.M.]]
</StructureSection>
[[Category: Kennard, O.]]
[[Category: Large Structures]]
[[Category: Lin, P.K.T.]]
[[Category: Brown DM]]
[[Category: Meervelt, L.Van.]]
[[Category: Kennard O]]
[[Category: Moore, M.H.]]
[[Category: Lin PKT]]
[[Category: double helix]]
[[Category: Moore MH]]
[[Category: modified]]
[[Category: Van Meervelt L]]
[[Category: z-dna]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 02:51:43 2007''

Latest revision as of 06:51, 7 February 2024

MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGMO4CG): N4-METHOXYCYTOSINE/GUANINE BASE-PAIRS IN Z-DNA

1da2, resolution 1.70Å

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