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New page: left|200px<br /><applet load="1pup" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pup, resolution 1.700Å" /> '''CRYSTAL STRUCTURE O...
 
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[[Image:1pup.gif|left|200px]]<br /><applet load="1pup" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1pup, resolution 1.700&Aring;" />
'''CRYSTAL STRUCTURE OF A PEPTIDE NUCLEIC ACID (PNA) DUPLEX AT 1.7 ANGSTROMS RESOLUTION'''<br />


==Overview==
==CRYSTAL STRUCTURE OF A PEPTIDE NUCLEIC ACID (PNA) DUPLEX AT 1.7 ANGSTROMS RESOLUTION==
The crystal structure of a PNA duplex reveals both a right- and a, left-handed helix in the unit cell. The helices are wide (28A), large, pitched (18bp) with the base pairs perpendicular to the helix axis, thereby demonstrating that PNA besides adapting to oligonucleotide, partners also has a unique structure by itself.
<StructureSection load='1pup' size='340' side='right'caption='[[1pup]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1pup]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PUP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-ADENINE'>APN</scene>, <scene name='pdbligand=CPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-CYTOSINE'>CPN</scene>, <scene name='pdbligand=GPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-GUANINE'>GPN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=TPN:2-AMINOETHYLGLYCINE-CARBONYLMETHYLENE-THYMINE'>TPN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pup OCA], [https://pdbe.org/1pup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pup RCSB], [https://www.ebi.ac.uk/pdbsum/1pup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pup ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of a PNA duplex reveals both a right- and a left-handed helix in the unit cell. The helices are wide (28A), large pitched (18bp) with the base pairs perpendicular to the helix axis, thereby demonstrating that PNA besides adapting to oligonucleotide partners also has a unique structure by itself.


==About this Structure==
Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 A resolution.,Rasmussen H, Kastrup JS, Nielsen JN, Nielsen JM, Nielsen PE Nat Struct Biol. 1997 Feb;4(2):98-101. PMID:9033585<ref>PMID:9033585</ref>
1PUP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with NH2 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PUP OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 A resolution., Rasmussen H, Kastrup JS, Nielsen JN, Nielsen JM, Nielsen PE, Nat Struct Biol. 1997 Feb;4(2):98-101. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9033585 9033585]
</div>
[[Category: Protein complex]]
<div class="pdbe-citations 1pup" style="background-color:#fffaf0;"></div>
[[Category: Kastrup, J.S.]]
== References ==
[[Category: Rasmussen, H.]]
<references/>
[[Category: NH2]]
__TOC__
[[Category: dna analogue]]
</StructureSection>
[[Category: double helix]]
[[Category: Large Structures]]
[[Category: peptide nucleic acid]]
[[Category: Kastrup JS]]
 
[[Category: Rasmussen H]]
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:02:25 2007''
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