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New page: left|200px<br /><applet load="1ljx" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ljx, resolution 1.64Å" /> '''THE STRUCTURE OF D(T...
 
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[[Image:1ljx.gif|left|200px]]<br /><applet load="1ljx" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1ljx, resolution 1.64&Aring;" />
'''THE STRUCTURE OF D(TPGPCPGPCPA)2 AT 293K: COMPARISON OF THE EFFECT OF SEQUENCE AND TEMPERATURE'''<br />


==Overview==
==THE STRUCTURE OF D(TPGPCPGPCPA)2 AT 293K: COMPARISON OF THE EFFECT OF SEQUENCE AND TEMPERATURE==
The crystal structure of a hexameric DNA fragment with the sequence, d(TGCGCA)(2) has been solved and refined at 293 K at a resolution of 1.64, A. The molecule adopts a left-handed Z-type helical conformation which is, common in alternating pyrimidine-purine sequences. The presence of A.T, base pairs at the two terminals does not perturb the structure to any, great degree. However, several sequence-specific microstructural changes, are noticeable. The structure of the identical sequence determined at 120, K involving somewhat different crystallization conditions has been, reported previously [Harper et al. (1998), Acta Cryst. D54, 1273-1284]. A, comparison of the present structure with that at low temperature and with, that of d(CGCGCG)(2) shows that the effect of the change in sequence is, greater than the combined effect of changes in temperature and, environment.
<StructureSection load='1ljx' size='340' side='right'caption='[[1ljx]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ljx]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LJX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ljx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ljx OCA], [https://pdbe.org/1ljx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ljx RCSB], [https://www.ebi.ac.uk/pdbsum/1ljx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ljx ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of a hexameric DNA fragment with the sequence d(TGCGCA)(2) has been solved and refined at 293 K at a resolution of 1.64 A. The molecule adopts a left-handed Z-type helical conformation which is common in alternating pyrimidine-purine sequences. The presence of A.T base pairs at the two terminals does not perturb the structure to any great degree. However, several sequence-specific microstructural changes are noticeable. The structure of the identical sequence determined at 120 K involving somewhat different crystallization conditions has been reported previously [Harper et al. (1998), Acta Cryst. D54, 1273-1284]. A comparison of the present structure with that at low temperature and with that of d(CGCGCG)(2) shows that the effect of the change in sequence is greater than the combined effect of changes in temperature and environment.


==About this Structure==
Structure of d(TGCGCA)2 at 293 K: comparison of the effects of sequence and temperature.,Thiyagarajan S, Satheesh Kumar P, Rajan SS, Gautham N Acta Crystallogr D Biol Crystallogr. 2002 Aug;58(Pt 8):1381-4. Epub 2002, Jul 20. PMID:12136163<ref>PMID:12136163</ref>
1LJX is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LJX OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structure of d(TGCGCA)2 at 293 K: comparison of the effects of sequence and temperature., Thiyagarajan S, Satheesh Kumar P, Rajan SS, Gautham N, Acta Crystallogr D Biol Crystallogr. 2002 Aug;58(Pt 8):1381-4. Epub 2002, Jul 20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12136163 12136163]
</div>
[[Category: Protein complex]]
<div class="pdbe-citations 1ljx" style="background-color:#fffaf0;"></div>
[[Category: Gautham, N.]]
== References ==
[[Category: Kumar, P.Satheesh.]]
<references/>
[[Category: Rajan, S.S.]]
__TOC__
[[Category: Thiyagarajan, S.]]
</StructureSection>
[[Category: MG]]
[[Category: Large Structures]]
[[Category: z-dna hexamer with at base pairs at the terminal]]
[[Category: Gautham N]]
 
[[Category: Rajan SS]]
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:03:13 2007''
[[Category: Satheesh Kumar P]]
[[Category: Thiyagarajan S]]

Latest revision as of 09:15, 16 August 2023

THE STRUCTURE OF D(TPGPCPGPCPA)2 AT 293K: COMPARISON OF THE EFFECT OF SEQUENCE AND TEMPERATURE

1ljx, resolution 1.64Å

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