3gpx: Difference between revisions

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{{Seed}}
[[Image:3gpx.jpg|left|200px]]


<!--
==Sequence-matched MutM Interrogation Complex 4 (IC4)==
The line below this paragraph, containing "STRUCTURE_3gpx", creates the "Structure Box" on the page.
<StructureSection load='3gpx' size='340' side='right'caption='[[3gpx]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3gpx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GPX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3gpx| PDB=3gpx |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gpx OCA], [https://pdbe.org/3gpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gpx RCSB], [https://www.ebi.ac.uk/pdbsum/3gpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gpx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P84131_GEOSE P84131_GEOSE] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gp/3gpx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gpx ConSurf].
<div style="clear:both"></div>


===Sequence-matched MutM Interrogation Complex 4 (IC4)===
==See Also==
 
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
3GPX is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GPX OCA].
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Qi, Y.]]
[[Category: Large Structures]]
[[Category: Spong, M C.]]
[[Category: Qi Y]]
[[Category: Verdine, G L.]]
[[Category: Spong MC]]
[[Category: Base extrusion]]
[[Category: Verdine GL]]
[[Category: Damage search]]
[[Category: Disulfide crosslinking]]
[[Category: Dna damage]]
[[Category: Dna glycosylase]]
[[Category: Dna repair]]
[[Category: Dna-binding]]
[[Category: Glycosidase]]
[[Category: Hydrolase]]
[[Category: Lyase]]
[[Category: Lyase/dna complex]]
[[Category: Metal-binding]]
[[Category: Multifunctional enzyme]]
[[Category: Zinc]]
[[Category: Zinc-finger]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov 11 22:24:36 2009''
Retrieved from "https://proteopedia.org/3gpx"