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New page: left|200px<br /><applet load="1dn6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1dn6, resolution 3.000Å" /> '''THE CRYSTAL STRUCTU...
 
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[[Image:1dn6.gif|left|200px]]<br /><applet load="1dn6" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1dn6, resolution 3.000&Aring;" />
'''THE CRYSTAL STRUCTURE OF D(GGATGGGAG). AN ESSENTIAL PART OF THE BINDING SITE FOR TRANSCRIPTION FACTOR IIIA'''<br />


==Overview==
==THE CRYSTAL STRUCTURE OF D(GGATGGGAG). AN ESSENTIAL PART OF THE BINDING SITE FOR TRANSCRIPTION FACTOR IIIA==
Most genes in higher organisms are activated by the binding of proteins, called transcription factors. One such protein, transcription factor IIIA, (TFIIIA) from the frog, activates the gene for 5S RNA by binding to the, region of the gene between nucleotides 45 and 97. This binding site has, been defined by a variety of biochemical studies, including base-deletion, experiments and DNase I footprinting. The protein also binds to the gene, product: in immature frogs it is stored as a complex with 5S RNA. From the, observation that TFIIIA can bind to either double-helical DNA or RNA, and, from their own measurements, Rhodes and Klug have proposed that the, DNA-binding site for TFIIIA has an RNA-like structure. Here we present the, crystal structure analysis of a part of the DNA-binding site (nucleotides, 81-89 of the gene) which forms a particularly strong interaction with the, protein, and show that it has a conformation similar to the A' form of, double-helical RNA.
<StructureSection load='1dn6' size='340' side='right'caption='[[1dn6]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1dn6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DN6 FirstGlance]. <br>
1DN6 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1DN6 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dn6 OCA], [https://pdbe.org/1dn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dn6 RCSB], [https://www.ebi.ac.uk/pdbsum/1dn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dn6 ProSAT]</span></td></tr>
==Reference==
</table>
The crystal structure of d(GGATGGGAG): an essential part of the binding site for transcription factor IIIA., McCall M, Brown T, Hunter WN, Kennard O, Nature. 1986 Aug 14-20;322(6080):661-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=3748146 3748146]
__TOC__
[[Category: Protein complex]]
</StructureSection>
[[Category: Brown, T.]]
[[Category: Large Structures]]
[[Category: Hunter, W.N.]]
[[Category: Brown T]]
[[Category: Kennard, O.]]
[[Category: Hunter WN]]
[[Category: McCall, M.]]
[[Category: Kennard O]]
[[Category: a-dna]]
[[Category: McCall M]]
[[Category: double helix]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:21:34 2007''

Latest revision as of 06:56, 7 February 2024

THE CRYSTAL STRUCTURE OF D(GGATGGGAG). AN ESSENTIAL PART OF THE BINDING SITE FOR TRANSCRIPTION FACTOR IIIA

1dn6, resolution 3.00Å

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