1i47: Difference between revisions
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New page: left|200px<br /><applet load="1i47" size="450" color="white" frame="true" align="right" spinBox="true" caption="1i47, resolution 2.1Å" /> '''MOLECULAR AND CRYSTAL... |
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== | ==MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA== | ||
To investigate the mutation mechanism of purine transition in DNA damaged | <StructureSection load='1i47' size='340' side='right'caption='[[1i47]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1i47]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I47 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C45:N4-METHOXY-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>C45</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i47 OCA], [https://pdbe.org/1i47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i47 RCSB], [https://www.ebi.ac.uk/pdbsum/1i47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i47 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
To investigate the mutation mechanism of purine transition in DNA damaged with methoxyamine, a DNA dodecamer with the sequence d(CGCGAATTmo(4)CGCG), where mo(4)C is 2'-deoxy-N(4)-methoxycytidine, has been synthesized and its crystal structure determined. Two dodecamers form a B-form duplex. Electron density maps clearly show that one of the two mo(4)C residues forms a pair with a guanine residue of the opposite strand, the geometry being the canonical Watson-Crick type, and that the other mo(4)C residue forms a wobble pair with the opposite guanine residue. These two pairings are ascribed to the tautomerization of the methoxylated cytosine moieties between the amino and imino forms. | |||
Crystallographic studies on damaged DNAs: III. N(4)-methoxycytosine can form both Watson-Crick type and wobbled base pairs in a B-form duplex.,Hossain MT, Chatake T, Hikima T, Tsunoda M, Sunami T, Ueno Y, Matsuda A, Takenaka A J Biochem. 2001 Jul;130(1):9-12. PMID:11432773<ref>PMID:11432773</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
[[Category: | <div class="pdbe-citations 1i47" style="background-color:#fffaf0;"></div> | ||
[[Category: Chatake | == References == | ||
[[Category: Hikima | <references/> | ||
[[Category: Hossain | __TOC__ | ||
[[Category: Matsuda | </StructureSection> | ||
[[Category: Sunami | [[Category: Large Structures]] | ||
[[Category: Takenaka | [[Category: Chatake T]] | ||
[[Category: Tsunoda | [[Category: Hikima T]] | ||
[[Category: Ueno | [[Category: Hossain MT]] | ||
[[Category: Matsuda A]] | |||
[[Category: Sunami T]] | |||
[[Category: Takenaka A]] | |||
[[Category: Tsunoda M]] | |||
[[Category: Ueno Y]] | |||
Latest revision as of 06:20, 9 August 2023
MOLECULAR AND CRYSTAL STRUCTURE OF D(CGCGAATT(MO4)CGCG): THE WATSON-CRICK TYPE AND WOBBLE N4-METHOXYCYTIDINE/GUANOSINE BASE PAIRS IN B-DNA
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