1m6r: Difference between revisions

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New page: left|200px<br /><applet load="1m6r" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m6r, resolution 1.54Å" /> '''Crystal structure of...
 
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[[Image:1m6r.gif|left|200px]]<br /><applet load="1m6r" size="450" color="white" frame="true" align="right" spinBox="true"
==Crystal structure of rGd(CGCGCG) forming hexamer Z-DNA duplex with 5'-(rG) overhang==
caption="1m6r, resolution 1.54&Aring;" />
<StructureSection load='1m6r' size='340' side='right' caption='[[1m6r]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
'''Crystal structure of rGd(CGCGCG) forming hexamer Z-DNA duplex with 5'-(rG) overhang'''<br />
== Structural highlights ==
<table><tr><td colspan='2'>[[1m6r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M6R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1M6R FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m6r OCA], [http://pdbe.org/1m6r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1m6r RCSB], [http://www.ebi.ac.uk/pdbsum/1m6r PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the heptamer rGd(CGCGCG) has been determined at 1.54 A resolution with R(work) and R(free) of 0.191 and 0.235, respectively. The crystal belongs to space group P2(1)2(1)2(1), with unit-cell parameters a = 17.96, b = 31.47, c = 44.73 A and two independent strands in the asymmetric unit. The chimera forms a Z-DNA hexamer duplex d(CGCGCG)(2), with the 5'-overhang rG invisible in the density. The replacement of rG in the 5' terminus of d(GCGCGCG) changes the reverse Hoogsteen G.G base pairing of the 5'-overhang dG (Pan et al., 1997). However, the replacement does not change the helix from Z-form to A-form or the water-structure motifs in the Z-DNA double-helical structure.


==Overview==
Crystal structure of rGd(CGCGCG): a Z-DNA hexamer duplex with a 5'-(rG) overhang.,Pan B, Sundaralingam M Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):433-7. Epub 2003, Feb 21. PMID:12595699<ref>PMID:12595699</ref>
The crystal structure of the heptamer rGd(CGCGCG) has been determined at, 1.54 A resolution with R(work) and R(free) of 0.191 and 0.235, respectively. The crystal belongs to space group P2(1)2(1)2(1), with, unit-cell parameters a = 17.96, b = 31.47, c = 44.73 A and two independent, strands in the asymmetric unit. The chimera forms a Z-DNA hexamer duplex, d(CGCGCG)(2), with the 5'-overhang rG invisible in the density. The, replacement of rG in the 5' terminus of d(GCGCGCG) changes the reverse, Hoogsteen G.G base pairing of the 5'-overhang dG (Pan et al., 1997)., However, the replacement does not change the helix from Z-form to A-form, or the water-structure motifs in the Z-DNA double-helical structure.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1M6R is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1M6R OCA].
</div>
 
<div class="pdbe-citations 1m6r" style="background-color:#fffaf0;"></div>
==Reference==
== References ==
Crystal structure of rGd(CGCGCG): a Z-DNA hexamer duplex with a 5'-(rG) overhang., Pan B, Sundaralingam M, Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):433-7. Epub 2003, Feb 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12595699 12595699]
<references/>
[[Category: Protein complex]]
__TOC__
[[Category: Pan, B.]]
</StructureSection>
[[Category: Sundaralingam, M.]]
[[Category: Pan, B]]
[[Category: overhang]]
[[Category: Sundaralingam, M]]
[[Category: z-dna]]
[[Category: Dna]]
 
[[Category: Overhang]]
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 03:52:49 2007''
[[Category: Z-dna]]
Retrieved from "https://proteopedia.org/1m6r"