1qh2: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /><applet load="1qh2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qh2" /> '''CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA A... |
No edit summary |
||
| (13 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
== | ==CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA== | ||
Female reproductive tissues of the ornamental tobacco amass high levels of | <StructureSection load='1qh2' size='340' side='right'caption='[[1qh2]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1qh2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QH2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qh2 OCA], [https://pdbe.org/1qh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qh2 RCSB], [https://www.ebi.ac.uk/pdbsum/1qh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qh2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q40378_NICAL Q40378_NICAL] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family. | |||
A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein.,Lee MC, Scanlon MJ, Craik DJ, Anderson MA Nat Struct Biol. 1999 Jun;6(6):526-30. PMID:10360353<ref>PMID:10360353</ref> | |||
== | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | |||
<div class="pdbe-citations 1qh2" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Nicotiana alata]] | [[Category: Nicotiana alata]] | ||
[[Category: Anderson MA]] | |||
[[Category: Anderson | [[Category: Craik DJ]] | ||
[[Category: Craik | [[Category: Lee MCS]] | ||
[[Category: Lee | [[Category: Scanlon MJ]] | ||
[[Category: Scanlon | |||
Latest revision as of 09:19, 6 December 2023
CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA
| ||||||||||||
