1z3f: Difference between revisions

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New page: left|200px<br /><applet load="1z3f" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z3f, resolution 1.50Å" /> '''Structure of ellipti...
 
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[[Image:1z3f.gif|left|200px]]<br /><applet load="1z3f" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1z3f, resolution 1.50&Aring;" />
'''Structure of ellipticine in complex with a 6-bp DNA'''<br />


==Overview==
==Structure of ellipticine in complex with a 6-bp DNA==
Ellipticine is a natural plant product that has been found to be a, powerful anticancer drug. Although still unclear, its mechanism of action, is considered to be mainly based on DNA intercalation and/or the, inhibition of topoisomerase II. Many experimental data suggest an, intercalation based on stacking interactions along the major base-pair, axis, but alternative binding modes have been proposed, in particular for, ellipticine derivatives. The 1.5 A resolution structure of ellipticine, complexed to a 6 bp oligonucleotide unveils its mode of binding and, enables a detailed analysis of the distorting effects of the drug on the, DNA.
<StructureSection load='1z3f' size='340' side='right'caption='[[1z3f]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1z3f]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Z3F FirstGlance]. <br>
1Z3F is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with EL and CO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EL:ELLIPTICINE'>EL</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z3f OCA], [https://pdbe.org/1z3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z3f RCSB], [https://www.ebi.ac.uk/pdbsum/1z3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z3f ProSAT]</span></td></tr>
The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs., Canals A, Purciolas M, Aymami J, Coll M, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):1009-12. Epub 2005, Jun 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15983425 15983425]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Aymami, J.]]
</StructureSection>
[[Category: Canals, A.]]
[[Category: Large Structures]]
[[Category: Coll, M.]]
[[Category: Aymami J]]
[[Category: Purciolas, M.]]
[[Category: Canals A]]
[[Category: CO]]
[[Category: Coll M]]
[[Category: EL]]
[[Category: Purciolas M]]
[[Category: anticancer]]
[[Category: dna binding]]
[[Category: drug design]]
[[Category: ellipticine]]
[[Category: intercalator]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 04:43:20 2007''

Latest revision as of 09:02, 14 February 2024

Structure of ellipticine in complex with a 6-bp DNA

1z3f, resolution 1.50Å

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