3g45: Difference between revisions

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{{Seed}}
[[Image:3g45.jpg|left|200px]]


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==Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988==
The line below this paragraph, containing "STRUCTURE_3g45", creates the "Structure Box" on the page.
<StructureSection load='3g45' size='340' side='right'caption='[[3g45]], [[Resolution|resolution]] 2.63&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3g45]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3G45 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.63&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=988:8-(3-NITROPHENYL)-6-(PYRIDIN-4-YLMETHYL)QUINOLINE'>988</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3g45| PDB=3g45 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3g45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3g45 OCA], [https://pdbe.org/3g45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3g45 RCSB], [https://www.ebi.ac.uk/pdbsum/3g45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3g45 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/3g45_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3g45 ConSurf].
<div style="clear:both"></div>


===Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988===
==See Also==
 
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_20037581}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 20037581 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_20037581}}
 
==About this Structure==
3G45 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3G45 OCA].
 
==Reference==
<ref group="xtra">PMID:20037581</ref><references group="xtra"/>
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Staker, B L.]]
[[Category: Large Structures]]
[[Category: Alternative splicing]]
[[Category: Staker BL]]
[[Category: Camp]]
[[Category: Hydrolase]]
[[Category: Phosphodiesterase]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 20 15:43:32 2010''

Latest revision as of 09:52, 21 February 2024

Crystal structure of human phosphodiesterase 4b with regulatory domain and d155988

3g45, resolution 2.63Å

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