1wfb: Difference between revisions

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{{Seed}}
[[Image:1wfb.png|left|200px]]


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==WINTER FLOUNDER ANTIFREEZE PROTEIN ISOFORM HPLC6 AT-180 DEGREES C==
The line below this paragraph, containing "STRUCTURE_1wfb", creates the "Structure Box" on the page.
<StructureSection load='1wfb' size='340' side='right'caption='[[1wfb]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1wfb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudopleuronectes_americanus Pseudopleuronectes americanus]. The December 2009 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Antifreeze Proteins''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2009_12 10.2210/rcsb_pdb/mom_2009_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WFB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
{{STRUCTURE_1wfb|  PDB=1wfb  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wfb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wfb OCA], [https://pdbe.org/1wfb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wfb RCSB], [https://www.ebi.ac.uk/pdbsum/1wfb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wfb ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ANPA_PSEAM ANPA_PSEAM] Antifreeze proteins lower the blood freezing point.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Antifreeze proteins provide fish with protection against the freezing effect of polar environments by binding to ice surfaces and inhibiting growth of ice crystals. We present the X-ray crystal structure at 1.5 A resolution of a lone alpha-helical antifreeze protein from winter flounder, which provides a detailed look at its ice-binding features. These consist of four repeated ice-binding motifs, the side chains of which are inherently rigid or restrained by pair-wise side-chain interactions to form a flat binding surface. Elaborate amino- and carboxy-terminal cap structures are also present, which explain the protein's rich alpha-helical content in solution. We propose an ice-binding model that accounts for the binding specificity of the antifreeze protein along the &lt;0112&gt; axes of the (2021) ice planes.


===WINTER FLOUNDER ANTIFREEZE PROTEIN ISOFORM HPLC6 AT-180 DEGREES C===
Ice-binding structure and mechanism of an antifreeze protein from winter flounder.,Sicheri F, Yang DS Nature. 1995 Jun 1;375(6530):427-31. PMID:7760940<ref>PMID:7760940</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1wfb" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_7760940}}, adds the Publication Abstract to the page
*[[Antifreeze protein 3D structures|Antifreeze protein 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 7760940 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_7760940}}
__TOC__
 
</StructureSection>
==About this Structure==
1WFB is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Pseudopleuronectes_americanus Pseudopleuronectes americanus]. The December 2009 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Antifreeze Proteins''  by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2009_12 10.2210/rcsb_pdb/mom_2009_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WFB OCA].
 
==Reference==
<ref group="xtra">PMID:7760940</ref><references group="xtra"/>
[[Category: Antifreeze Proteins]]
[[Category: Antifreeze Proteins]]
[[Category: Large Structures]]
[[Category: Pseudopleuronectes americanus]]
[[Category: Pseudopleuronectes americanus]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Sicheri, F.]]
[[Category: Sicheri F]]
[[Category: Yang, D S.C.]]
[[Category: Yang DSC]]
[[Category: Antifreeze polypeptide]]
[[Category: Ice binding protein]]
[[Category: Thermal hysteresis protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 21 08:56:47 2010''

Latest revision as of 11:25, 2 August 2023

WINTER FLOUNDER ANTIFREEZE PROTEIN ISOFORM HPLC6 AT-180 DEGREES C

1wfb, resolution 1.50Å

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