3lcj: Difference between revisions
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New page: '''Unreleased structure''' The entry 3lcj is ON HOLD Authors: Timofeev, V.I., Smirnova, E.A., Chupova, L.A., Esipov, R.S., Kuranova, I.P. Description: Phosphopantetheine adenylyltransf... |
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==Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis complexed with CoA== | |||
<StructureSection load='3lcj' size='340' side='right'caption='[[3lcj]], [[Resolution|resolution]] 2.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3lcj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LCJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LCJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lcj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lcj OCA], [https://pdbe.org/3lcj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lcj RCSB], [https://www.ebi.ac.uk/pdbsum/3lcj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lcj ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/COAD_MYCTU COAD_MYCTU] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lc/3lcj_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lcj ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Chupova LA]] | |||
[[Category: Esipov RS]] | |||
[[Category: Kuranova IP]] | |||
[[Category: Smirnova EA]] | |||
[[Category: Timofeev VI]] | |||
Latest revision as of 10:19, 21 February 2024
Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis complexed with CoA
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