3l0k: Difference between revisions

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{{Seed}}
[[Image:3l0k.jpg|left|200px]]


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==Human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP==
The line below this paragraph, containing "STRUCTURE_3l0k", creates the "Structure Box" on the page.
<StructureSection load='3l0k' size='340' side='right'caption='[[3l0k]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3l0k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ex0 3ex0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L0K FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.34&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6AU:6-ACETYLURIDINE+5-PHOSPHATE'>6AU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_3l0k| PDB=3l0k |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l0k OCA], [https://pdbe.org/3l0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l0k RCSB], [https://www.ebi.ac.uk/pdbsum/3l0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l0k ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN] Defects in UMPS are the cause of orotic aciduria type 1 (ORAC1) [MIM:[https://omim.org/entry/258900 258900]. A disorder of pyrimidine metabolism resulting in megaloblastic anemia and orotic acid crystalluria that is frequently associated with some degree of physical and mental retardation. A minority of cases have additional features, particularly congenital malformations and immune deficiencies.<ref>PMID:9042911</ref>
== Function ==
[https://www.uniprot.org/uniprot/UMPS_HUMAN UMPS_HUMAN]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/3l0k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l0k ConSurf].
<div style="clear:both"></div>


===Human orotidyl-5'-monophosphate decarboxylase in complex with 6-acetyl-UMP===
==See Also==
 
*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
 
*[[Uridine 5'-monophosphate synthase 3D structures|Uridine 5'-monophosphate synthase 3D structures]]
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== References ==
The line below this paragraph, {{ABSTRACT_PUBMED_19472232}}, adds the Publication Abstract to the page
<references/>
(as it appears on PubMed at http://www.pubmed.gov), where 19472232 is the PubMed ID number.
__TOC__
-->
</StructureSection>
{{ABSTRACT_PUBMED_19472232}}
 
==About this Structure==
3L0K is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3ex0 3ex0]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0K OCA].
 
==Reference==
<ref group="xtra">PMID:19472232</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Orotidine-5'-phosphate decarboxylase]]
[[Category: Large Structures]]
[[Category: Diederichsen, U.]]
[[Category: Diederichsen U]]
[[Category: Heinrich, D.]]
[[Category: Heinrich D]]
[[Category: Rudolph, M.]]
[[Category: Rudolph M]]
[[Category: Decarboxylase]]
[[Category: Multifunctional enzyme]]
[[Category: Pyrimidine biosynthesis]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 19:28:23 2010''
Retrieved from "https://proteopedia.org/3l0k"