3hju: Difference between revisions

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{{Seed}}
[[Image:3hju.png|left|200px]]


<!--
==Crystal structure of human monoglyceride lipase==
The line below this paragraph, containing "STRUCTURE_3hju", creates the "Structure Box" on the page.
<StructureSection load='3hju' size='340' side='right'caption='[[3hju]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3hju]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HJU FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_3hju| PDB=3hju |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hju OCA], [https://pdbe.org/3hju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hju RCSB], [https://www.ebi.ac.uk/pdbsum/3hju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hju ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MGLL_HUMAN MGLL_HUMAN] Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.<ref>PMID:20079333</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/3hju_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hju ConSurf].
<div style="clear:both"></div>


===Crystal structure of human monoglyceride lipase===
==See Also==
 
*[[Lipase 3D Structures|Lipase 3D Structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_19957260}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 19957260 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_19957260}}
 
==About this Structure==
3HJU is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HJU OCA].
 
==Reference==
<ref group="xtra">PMID:19957260</ref><references group="xtra"/>
[[Category: Acylglycerol lipase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bauvois, C.]]
[[Category: Large Structures]]
[[Category: Borel, F.]]
[[Category: Bauvois C]]
[[Category: Ferrer, J L.]]
[[Category: Borel F]]
[[Category: Labar, G.]]
[[Category: Ferrer J-L]]
[[Category: Lambert, D M.]]
[[Category: Labar G]]
[[Category: Wouters, J.]]
[[Category: Lambert DM]]
[[Category: Alpha/beta hydrolase]]
[[Category: Wouters J]]
[[Category: Hydrolase]]
[[Category: Serine esterase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 27 19:52:05 2010''
Retrieved from "https://proteopedia.org/3hju"