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{{Seed}}
[[Image:3ibp.jpg|left|200px]]


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==The Crystal Structure of the Dimerization Domain of Escherichia coli Structural Maintenance of Chromosomes Protein MukB==
The line below this paragraph, containing "STRUCTURE_3ibp", creates the "Structure Box" on the page.
<StructureSection load='3ibp' size='340' side='right'caption='[[3ibp]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ibp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IBP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IBP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.099&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene></td></tr>
{{STRUCTURE_3ibp|  PDB=3ibp  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ibp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ibp OCA], [https://pdbe.org/3ibp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ibp RCSB], [https://www.ebi.ac.uk/pdbsum/3ibp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ibp ProSAT]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ib/3ibp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ibp ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
MukB, a divergent structural maintenance of chromosomes (SMC) protein, is important for chromosomal segregation and condensation in gamma-proteobacteria. MukB and canonical SMC proteins share a characteristic five-domain structure. Globular N- and C-terminal domains interact to form an ATP-binding cassette-like ATPase or "head" domain, which is connected to a smaller dimerization or "hinge" domain by a long, antiparallel coiled coil. In addition to mediating dimerization, this hinge region has been implicated in both conformational flexibility and dynamic protein-DNA interactions. We report here the first crystallographic model of the MukB hinge domain. This model also contains approximately 20% of the coiled-coil domain, including an unusual coiled-coil deviation. These results will facilitate studies to clarify the roles of both the hinge and the coiled-coil domains in MukB function.


===The Crystal Structure of the Dimerization Domain of Escherichia coli Structural Maintenance of Chromosomes Protein MukB===
The crystal structure of the hinge domain of the Escherichia coli structural maintenance of chromosomes protein MukB.,Li Y, Schoeffler AJ, Berger JM, Oakley MG J Mol Biol. 2010 Jan 8;395(1):11-9. Epub 2009 Oct 22. PMID:19853611<ref>PMID:19853611</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3ibp" style="background-color:#fffaf0;"></div>


==About this Structure==
==See Also==
3IBP is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IBP OCA].
*[[Condensin|Condensin]]
[[Category: Escherichia coli k-12]]
== References ==
[[Category: Berger, J M.]]
<references/>
[[Category: Li, Y.]]
__TOC__
[[Category: Oakley, M G.]]
</StructureSection>
[[Category: Schoeffler, A J.]]
[[Category: Escherichia coli K-12]]
[[Category: Atp-binding]]
[[Category: Large Structures]]
[[Category: Cell cycle]]
[[Category: Berger JM]]
[[Category: Cell division]]
[[Category: Li Y]]
[[Category: Chromosome partition]]
[[Category: Oakley MG]]
[[Category: Chromosome segregation]]
[[Category: Schoeffler AJ]]
[[Category: Cohesin]]
[[Category: Coiled coil]]
[[Category: Condensin]]
[[Category: Cytoplasm]]
[[Category: Dimerization domain]]
[[Category: Dna condensation]]
[[Category: Dna-binding]]
[[Category: Hinge]]
[[Category: Mukb]]
[[Category: Nucleotide-binding]]
[[Category: Smc]]
[[Category: Structural maintenance of chromosome]]
 
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Retrieved from "https://proteopedia.org/3ibp"