3i1y: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(7 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:3i1y.png|left|200px]]


<!--
==Crystal Structure of soluble epoxide Hydrolase==
The line below this paragraph, containing "STRUCTURE_3i1y", creates the "Structure Box" on the page.
<StructureSection load='3i1y' size='340' side='right'caption='[[3i1y]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3i1y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I1Y FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.469&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=33N:N-(3,3-DIPHENYLPROPYL)PYRIDINE-3-CARBOXAMIDE'>33N</scene></td></tr>
{{STRUCTURE_3i1y| PDB=3i1y |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i1y OCA], [https://pdbe.org/3i1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i1y RCSB], [https://www.ebi.ac.uk/pdbsum/3i1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i1y ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/3i1y_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i1y ConSurf].
<div style="clear:both"></div>


===Crystal Structure of soluble epoxide Hydrolase===
==See Also==
 
*[[Epoxide hydrolase 3D structures|Epoxide hydrolase 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_19746975}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 19746975 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_19746975}}
 
==Disease==
Known disease associated with this structure: Hypercholesterolemia, familial, due to LDLR defect, modifier of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=132811 132811]]
 
==About this Structure==
3I1Y is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I1Y OCA].
 
==Reference==
<ref group="xtra">PMID:19746975</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Soluble epoxide hydrolase]]
[[Category: Large Structures]]
[[Category: Farrow, N A.]]
[[Category: Farrow NA]]
[[Category: Aromatic hydrocarbons catabolism]]
[[Category: Cytoplasm]]
[[Category: Detoxification]]
[[Category: Hydrolase]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Peroxisome]]
[[Category: Polymorphism]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jan 28 14:32:41 2010''

Latest revision as of 10:02, 21 February 2024

Crystal Structure of soluble epoxide Hydrolase

3i1y, resolution 2.47Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=3i1y&oldid=4065469"