3ggh: Difference between revisions

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{{Seed}}
[[Image:3ggh.png|left|200px]]


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==Donor strand complemented FaeG of F4ad fimbriae==
The line below this paragraph, containing "STRUCTURE_3ggh", creates the "Structure Box" on the page.
<StructureSection load='3ggh' size='340' side='right'caption='[[3ggh]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ggh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GGH FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.639&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3ggh|  PDB=3ggh  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ggh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ggh OCA], [https://pdbe.org/3ggh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ggh RCSB], [https://www.ebi.ac.uk/pdbsum/3ggh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ggh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FAEG3_ECOLX FAEG3_ECOLX] K88 major fimbrial subunit. Fimbriae (also called pili), are polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell. They enable bacteria to colonize the epithelium of specific host organs.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/3ggh_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ggh ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Enterotoxigenic Escherichia coli expressing F4 fimbriae are the major cause of porcine colibacillosis and are responsible for significant death and morbidity in neonatal and postweaned piglets. Via the chaperone-usher pathway, F4 fimbriae are assembled into thin, flexible polymers mainly composed of the single-domain adhesin FaeG. The F4 fimbrial system has been labeled eccentric because the F4 pilins show some features distinct from the features of pilins of other chaperone-usher-assembled structures. In particular, FaeG is much larger than other pilins (27 versus approximately 17 kDa), grafting an additional carbohydrate binding domain on the common immunoglobulin-like core. Structural data of FaeG during different stages of the F4 fimbrial biogenesis process, combined with differential scanning calorimetry measurements, confirm the general principles of the donor strand complementation/exchange mechanisms taking place during pilus biogenesis via the chaperone-usher pathway.


===Donor strand complemented FaeG of F4ad fimbriae===
Structural and thermodynamic characterization of pre- and postpolymerization states in the F4 fimbrial subunit FaeG.,Van Molle I, Moonens K, Garcia-Pino A, Buts L, De Kerpel M, Wyns L, Bouckaert J, De Greve H J Mol Biol. 2009 Dec 18;394(5):957-67. Epub 2009 Sep 30. PMID:19799915<ref>PMID:19799915</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3ggh" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_19799915}}, adds the Publication Abstract to the page
*[[Pilin 3D structures|Pilin 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 19799915 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_19799915}}
__TOC__
 
</StructureSection>
==About this Structure==
3GGH is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GGH OCA].
 
==Reference==
<ref group="xtra">PMID:19799915</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Bouckaert, J.]]
[[Category: Large Structures]]
[[Category: Buts, L.]]
[[Category: Bouckaert J]]
[[Category: Garcia-Pino, A.]]
[[Category: Buts L]]
[[Category: Greve, H De.]]
[[Category: De Greve H]]
[[Category: Molle, I Van.]]
[[Category: Garcia-Pino A]]
[[Category: Moonens, K.]]
[[Category: Moonens K]]
[[Category: Cell adhesion]]
[[Category: Van Molle I]]
[[Category: Fimbrium]]
[[Category: Immunoglobulin like fold]]
[[Category: Plasmid]]
 
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Retrieved from "https://proteopedia.org/3ggh"