3c6r: Difference between revisions

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{{Seed}}
[[Image:3c6r.png|left|200px]]


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==Low pH Immature Dengue Virus==
The line below this paragraph, containing "STRUCTURE_3c6r", creates the "Structure Box" on the page.
<SX load='3c6r' size='340' side='right' viewer='molstar' caption='[[3c6r]], [[Resolution|resolution]] 25.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3c6r]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2_Thailand/PUO-218/1980 Dengue virus 2 Thailand/PUO-218/1980]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C6R FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c6r OCA], [https://pdbe.org/3c6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c6r RCSB], [https://www.ebi.ac.uk/pdbsum/3c6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c6r ProSAT]</span></td></tr>
{{STRUCTURE_3c6r|  PDB=3c6r  |  SCENE=  }}
</table>
 
== Function ==
===Low pH Immature Dengue Virus===
[https://www.uniprot.org/uniprot/POLG_DEN2U POLG_DEN2U] prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated (By similarity).  Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).  Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity).
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_18369148}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18369148 is the PubMed ID number.
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c6/3c6r_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18369148}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c6r ConSurf].
3C6R is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C6R OCA].  
<div style="clear:both"></div>
 
__TOC__
==Reference==
</SX>
<ref group="xtra">PMID:18369148</ref><references group="xtra"/>
[[Category: Dengue virus 2 Thailand/PUO-218/1980]]
[[Category: Dengue virus 2]]
[[Category: Large Structures]]
[[Category: Chen, J.]]
[[Category: Chen J]]
[[Category: Chipman, P R.]]
[[Category: Chipman PR]]
[[Category: Holdway, H A.]]
[[Category: Holdway HA]]
[[Category: Kostyuchenko, V A.]]
[[Category: Kostyuchenko VA]]
[[Category: Kuhn, R J.]]
[[Category: Kuhn RJ]]
[[Category: Li, L.]]
[[Category: Li L]]
[[Category: Rossmann, M G.]]
[[Category: Rossmann MG]]
[[Category: Yu, I.]]
[[Category: Yu I]]
[[Category: Zhang, W.]]
[[Category: Zhang W]]
[[Category: Capsid protein]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Core protein]]
[[Category: Dengue]]
[[Category: Endoplasmic reticulum]]
[[Category: Envelope protein]]
[[Category: Glycoprotein]]
[[Category: Icosahedral virus]]
[[Category: Immature]]
[[Category: Membrane]]
[[Category: Prm]]
[[Category: Secreted]]
[[Category: Transmembrane]]
[[Category: Virion]]
[[Category: Virus]]
 
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Retrieved from "https://proteopedia.org/3c6r"