3a4r: Difference between revisions
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==The crystal structure of SUMO-like domain 2 in Nip45== | |||
<StructureSection load='3a4r' size='340' side='right'caption='[[3a4r]], [[Resolution|resolution]] 1.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3a4r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A4R FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a4r OCA], [https://pdbe.org/3a4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a4r RCSB], [https://www.ebi.ac.uk/pdbsum/3a4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a4r ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NF2IP_MOUSE NF2IP_MOUSE] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.<ref>PMID:20133688</ref> <ref>PMID:20077568</ref> | |||
== Evolutionary Conservation == | |||
< | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/3a4r_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
== | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a4r ConSurf]. | |||
<div style="clear:both"></div> | |||
== | == References == | ||
< | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Arita | [[Category: Arita K]] | ||
[[Category: Ariyoshi | [[Category: Ariyoshi M]] | ||
[[Category: Ikeda | [[Category: Ikeda Y]] | ||
[[Category: Saitoh | [[Category: Saitoh H]] | ||
[[Category: Sekiyama | [[Category: Sekiyama N]] | ||
[[Category: Shirakawa | [[Category: Shirakawa M]] | ||
[[Category: Tochio | [[Category: Tochio H]] | ||
Latest revision as of 13:59, 13 March 2024
The crystal structure of SUMO-like domain 2 in Nip45
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