3ipn: Difference between revisions

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{{Seed}}
[[Image:3ipn.jpg|left|200px]]


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==Crystal Structure of fluorine and methyl modified collagen: (mepFlpgly)7==
The line below this paragraph, containing "STRUCTURE_3ipn", creates the "Structure Box" on the page.
<StructureSection load='3ipn' size='340' side='right'caption='[[3ipn]], [[Resolution|resolution]] 1.21&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ipn]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IPN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.21&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FP9:(4R)-4-FLUORO-L-PROLINE'>FP9</scene>, <scene name='pdbligand=MP8:(4R)-4-METHYL-L-PROLINE'>MP8</scene></td></tr>
{{STRUCTURE_3ipn|  PDB=3ipn  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ipn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipn OCA], [https://pdbe.org/3ipn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ipn RCSB], [https://www.ebi.ac.uk/pdbsum/3ipn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipn ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Preorganization is shown to endow a protein with extraordinary conformational stability. This preorganization is achieved by installing side-chain substituents that impose stereoelectronic and steric effects that restrict main-chain torsion angles. Replacing proline residues in (ProProGly)(7) collagen strands with 4-fluoroproline and 4-methylproline leads to the most stable known triple helices, having T ( m ) values that are increased by &gt; 50 degrees C. Differential scanning calorimetry data indicate an entropic basis to the hyperstability, as expected from an origin in preorganization. Structural data at a resolution of 1.21 A reveal a prototypical triple helix with insignificant deviations to its main chain, even though 2/3 of the residues are nonnatural. Thus, preorganization of a main chain by subtle changes to side chains can confer extraordinary conformational stability upon a protein without perturbing its structure.


===Crystal Structure of fluorine and methyl modified collagen: (mepFlpgly)7===
Stereoelectronic and steric effects in side chains preorganize a protein main chain.,Shoulders MD, Satyshur KA, Forest KT, Raines RT Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):559-64. Epub 2009 Dec 31. PMID:20080719<ref>PMID:20080719</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3ipn" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_20080719}}, adds the Publication Abstract to the page
*[[Collagen 3D structures|Collagen 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 20080719 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_20080719}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3IPN is a 6 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPN OCA].
[[Category: Forest KT]]
 
[[Category: Raines RT]]
==Reference==
[[Category: Satyshur KA]]
<ref group="xtra">PMID:20080719</ref><references group="xtra"/>
[[Category: Shoulders MD]]
[[Category: Forest, K T.]]
[[Category: Raines, R T.]]
[[Category: Satyshur, K A.]]
[[Category: Shoulders, M D.]]
[[Category: Collagen]]
[[Category: Fluorinated methylated collagen]]
[[Category: Nonnatural amino acid]]
[[Category: Structural protein]]
 
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Retrieved from "https://proteopedia.org/3ipn"