2x4d: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: '''Unreleased structure''' The entry 2x4d is ON HOLD Authors: Vollmar, M., Gileadi, C., Guo, K., Savitsky, P., Muniz, J.R.C., Yue, W., Allerston, C., Von Delft, F., Bountra, C., Arrowsm... |
No edit summary |
||
| (11 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP== | |||
<StructureSection load='2x4d' size='340' side='right'caption='[[2x4d]], [[Resolution|resolution]] 1.92Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2x4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X4D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x4d OCA], [https://pdbe.org/2x4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x4d RCSB], [https://www.ebi.ac.uk/pdbsum/2x4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x4d ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/LHPP_HUMAN LHPP_HUMAN] Phosphatase that hydrolyzes imidodiphosphate, 3-phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x4d_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x4d ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Allerston C]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Edwards A]] | |||
[[Category: Gileadi C]] | |||
[[Category: Guo K]] | |||
[[Category: Kavanagh KL]] | |||
[[Category: Muniz JRC]] | |||
[[Category: Oppermann U]] | |||
[[Category: Savitsky P]] | |||
[[Category: Vollmar M]] | |||
[[Category: Weigelt J]] | |||
[[Category: Yue W]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 10:23, 20 December 2023
Crystal structure of human phospholysine phosphohistidine inorganic pyrophosphate phosphatase LHPP
| ||||||||||||
