Nathan Line sandbox 1: Difference between revisions

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==~~This is a placeholder~~==

==The Mechanism of Trypsin==

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~~Replace~~ the ~~PDB id (use lowercase!) after~~ the ~~STRUCTURE_~~ and ~~after PDB=~~ to ~~load~~

Trypsin is a serine protease that breaks down the backbone of peptides near positively charged side chains. [[2ah4]] The peptide is pulled into the active site by Asp 189. His 57 pulls on the hydrogen attached to the OH on Ser 195 to make it a better nucleophilie which attacks the carbonyl of the peptide. This tetrahedral intermediate removes the hydrogen from His 57 while the carbonyl reforms resulting in a break in the peptide backbone. After the amino group is replaced with water, the water again attacks the carbonyl and this tetrahedral collapses to reconstruct both the Ser195 and His57. The final products result in an amino group and a carboxylic acid compound.

and ~~display another structure~~.

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@@ Line 1: / Line 1: @@
-==This is a placeholder==
+==The Mechanism of Trypsin==
-This is a placeholder text to help you get started in
-placing a Jmol applet on your page. At any time, click
-"Show Preview" at the bottom of this page to see how it goes.
-Replace the PDB id (use lowercase!) after the STRUCTURE_ and after PDB= to load
+Trypsin is a serine protease that breaks down the backbone of peptides near positively charged side chains.  [[2ah4]] The peptide is pulled into the active site by Asp 189.  His 57 pulls on the hydrogen attached to the OH on Ser 195 to make it a better nucleophilie which attacks the carbonyl of the peptide.  This tetrahedral intermediate removes the hydrogen from His 57 while the carbonyl reforms resulting in a break in the peptide backbone.  After the amino group is replaced with water, the water again attacks the carbonyl and this tetrahedral collapses to reconstruct both the Ser195 and His57.  The final products result in an amino group and a carboxylic acid compound.
-and display another structure.
-{{STRUCTURE_3cin |  PDB=3cin  |  SCENE=  }}
+{{STRUCTURE_2ah4 |  PDB=2ah4  |  SCENE=  }}