3kys: Difference between revisions

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{{Seed}}
[[Image:3kys.jpg|left|200px]]


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==Crystal structure of human YAP and TEAD complex==
The line below this paragraph, containing "STRUCTURE_3kys", creates the "Structure Box" on the page.
<StructureSection load='3kys' size='340' side='right'caption='[[3kys]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3kys]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KYS FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P1L:S-PALMITOYL-L-CYSTEINE'>P1L</scene></td></tr>
{{STRUCTURE_3kys|  PDB=3kys  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kys OCA], [https://pdbe.org/3kys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kys RCSB], [https://www.ebi.ac.uk/pdbsum/3kys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kys ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN] Defects in TEAD1 are the cause of Sveinsson chorioretinal atrophy (SCRA) [MIM:[https://omim.org/entry/108985 108985]; also known as atrophia areata (AA) or helicoidal peripapillary chorioretinal degeneration (HPCD). SCRA is characterized by symmetrical lesions radiating from the optic disk involving the retina and the choroid.<ref>PMID:18579750</ref> <ref>PMID:20123905</ref> <ref>PMID:15016762</ref>
== Function ==
[https://www.uniprot.org/uniprot/TEAD1_HUMAN TEAD1_HUMAN] Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.<ref>PMID:18579750</ref> <ref>PMID:19324877</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ky/3kys_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kys ConSurf].
<div style="clear:both"></div>
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== Publication Abstract from PubMed ==
The Yes-associated protein (YAP) transcriptional coactivator is a key regulator of organ size and a candidate human oncogene inhibited by the Hippo tumor suppressor pathway. The TEAD family of transcription factors binds directly to and mediates YAP-induced gene expression. Here we report the three-dimensional structure of the YAP (residues 50-171)-TEAD1 (residues 194-411) complex, in which YAP wraps around the globular structure of TEAD1 and forms extensive interactions via three highly conserved interfaces. Interface 3, including YAP residues 86-100, is most critical for complex formation. Our study reveals the biochemical nature of the YAP-TEAD interaction, and provides a basis for pharmacological intervention of YAP-TEAD hyperactivation in human diseases.


===Crystal structure of human YAP and TEAD complex===
Structural insights into the YAP and TEAD complex.,Li Z, Zhao B, Wang P, Chen F, Dong Z, Yang H, Guan KL, Xu Y Genes Dev. 2010 Feb 1;24(3):235-40. PMID:20123905<ref>PMID:20123905</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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(as it appears on PubMed at http://www.pubmed.gov), where 20123905 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_20123905}}
__TOC__
 
</StructureSection>
==Disease==
Known disease associated with this structure: Sveinsson choreoretinal atrophy OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=189967 189967]]
 
==About this Structure==
3KYS is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KYS OCA].
 
==Reference==
<ref group="xtra">PMID:20123905</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, F.]]
[[Category: Large Structures]]
[[Category: Dong, Z.]]
[[Category: Chen F]]
[[Category: Guan, K L.]]
[[Category: Dong Z]]
[[Category: Li, Z.]]
[[Category: Guan KL]]
[[Category: Wang, P.]]
[[Category: Li Z]]
[[Category: Xu, Y.]]
[[Category: Wang P]]
[[Category: Yang, H.]]
[[Category: Xu Y]]
[[Category: Zhao, B.]]
[[Category: Yang H]]
[[Category: Activator]]
[[Category: Zhao B]]
[[Category: Disease mutation]]
[[Category: Dna-binding]]
[[Category: Immunoglobulin-like fold]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Transcription-protein binding complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 25 13:26:54 2010''
Retrieved from "https://proteopedia.org/3kys"