3k6t: Difference between revisions

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{{Seed}}
[[Image:3k6t.jpg|left|200px]]


<!--
==Crystal structure of the GLD-1 homodimerization domain from Caenorhabditis elegans at 2.04 A resolution==
The line below this paragraph, containing "STRUCTURE_3k6t", creates the "Structure Box" on the page.
<StructureSection load='3k6t' size='340' side='right'caption='[[3k6t]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3k6t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3K6T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3k6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3k6t OCA], [https://pdbe.org/3k6t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3k6t RCSB], [https://www.ebi.ac.uk/pdbsum/3k6t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3k6t ProSAT]</span></td></tr>
{{STRUCTURE_3k6t|  PDB=3k6t  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of the GLD-1 homodimerization domain from Caenorhabditis elegans at 2.04 A resolution===
[https://www.uniprot.org/uniprot/GLD1_CAEEL GLD1_CAEEL] Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline. Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation.
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
3K6T is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3K6T OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/3k6t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3k6t ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
[[Category: Beuck, C.]]
[[Category: Large Structures]]
[[Category: Carmel, A B.]]
[[Category: Beuck C]]
[[Category: Columbus, L.]]
[[Category: Carmel AB]]
[[Category: Kerkow, D E.]]
[[Category: Columbus L]]
[[Category: Stanfield, R L.]]
[[Category: Kerkow DE]]
[[Category: Szymczyna, B R.]]
[[Category: Stanfield RL]]
[[Category: Williamson, J R.]]
[[Category: Szymczyna BR]]
[[Category: Developmental protein]]
[[Category: Williamson JR]]
[[Category: Differentiation]]
[[Category: Gld-1]]
[[Category: Helix-turn-helix motif]]
[[Category: Hydrophobic homodimer interface]]
[[Category: Meiosis]]
[[Category: Oogenesis]]
[[Category: Perpendicular stacking of protomer]]
[[Category: Protein binding]]
[[Category: Qua1 homodimerization domain]]
[[Category: Rna-binding]]
[[Category: Translation regulation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 10 14:36:32 2010''
Retrieved from "https://proteopedia.org/3k6t"