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| =Alpha-Bungarotoxin= | | <Structure load='1stp' size='300' frame='true' align='right' caption='test' scene='' /> |
| Alpha-Bungarotoxin (α-BGT) is a nicotinic cholinergic antagonist that is found within the venom of ''Bungarus multicinctus'', a South-asian snake commonly known as kraits. α-BGT is known to bind irreversibly to the acetylcholine receptor found at the neuromuscular junction, causing respiratory failure, paralysis, and death, as well as play an antagonstic role in binding the α7 nicotinic acetylcholine receptor in the brain.
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| =Structure=
| | * <scene name='Sandbox_174/Xx1/1'>Always reload</scene> |
| | | * <scene name='Sandbox_174/Xx1/2'>Reload when needed</scene> |
| ==General Structure==
| | * <scene name='Sandbox_174/Xx1/3'>ALways</scene> |
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| =Functions=
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| ==α7 nicotinic acetylcholine receptor binding==
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| Reponse to sensory stimuli and seizure genesis has been linked to nicotinic mechanisms<ref name="main">PMID:18638483</ref>.
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| Seizure genesisa nd habituation of responseto sensorys timuli have been linked to nicotinic mechanisms (Marks et al., 1989;
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| Luntz-Leybman et al., 1992). These functions are closely associated
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| with the CA3 field (Schwartzkroin, 1986; Bickford-
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| Wimer et al., 1990). Nicotinic responsesa re mediated by two
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| major classeso f receptors, ganglionic type and neuromuscular
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| type. Pharmacological analysis of both seizure genesis and habituation
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| in rat brain implicates mediation by a neuromuscular
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| type (Miner and Collins, 1989; Luntz-Leybman et al., 1992).
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| These data are supported by the prominent binding of the neuromuscular-
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| type antagonist oc-bungarotoxin (a-BT) in the CA3
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| field of the hippocampus (Hunt and Schmidt, 1978; Segal et al.,
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| 1978; Clarke et al., 1985
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| ==neuromuscular acetylcholine receptor binding==
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| <applet load='2abx' size='300' frame='true' align='right' /> | |
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| <scene name='Sandbox_174/Newscene/1'>All residues</scene> | |
| <table style="background-color:#ffffc0" cellpadding="8" width="95%" border="0"><tr><td>Please do NOT make changes to this Sandbox until after April 23, 2010. Sandboxes 151-200 are reserved until then for use by the Chemistry 307 class at UNBC taught by Prof.[[User:Andrea Gorrell|Andrea Gorrell]].</td></tr> | |
