3kj0: Difference between revisions

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{{Seed}}
[[Image:3kj0.png|left|200px]]


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==Mcl-1 in complex with Bim BH3 mutant I2dY==
The line below this paragraph, containing "STRUCTURE_3kj0", creates the "Structure Box" on the page.
<StructureSection load='3kj0' size='340' side='right'caption='[[3kj0]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3kj0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KJ0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
{{STRUCTURE_3kj0|  PDB=3kj0  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kj0 OCA], [https://pdbe.org/3kj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kj0 RCSB], [https://www.ebi.ac.uk/pdbsum/3kj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kj0 ProSAT]</span></td></tr>
 
</table>
===Mcl-1 in complex with Bim BH3 mutant I2dY===
== Function ==
 
[https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref>  
 
== Evolutionary Conservation ==
<!--
[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_20066663}}, adds the Publication Abstract to the page
Check<jmol>
(as it appears on PubMed at http://www.pubmed.gov), where 20066663 is the PubMed ID number.
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/3kj0_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_20066663}}
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 
    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
3KJ0 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KJ0 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kj0 ConSurf].
 
<div style="clear:both"></div>
==Reference==
== References ==
<ref group="xtra">PMID:20066663</ref><references group="xtra"/>
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fire, E.]]
[[Category: Large Structures]]
[[Category: Grant, R A.]]
[[Category: Fire E]]
[[Category: Keating, A E.]]
[[Category: Grant RA]]
[[Category: Alternative splicing]]
[[Category: Keating AE]]
[[Category: Apoptosis]]
[[Category: Bcl-2]]
[[Category: Bh3]]
[[Category: Cytoplasm]]
[[Category: Developmental protein]]
[[Category: Differentiation]]
[[Category: Isopeptide bond]]
[[Category: Membrane]]
[[Category: Mitochondrion]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Protein-peptide complex]]
[[Category: Transmembrane]]
[[Category: Ubl conjugation]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:28:43 2010''

Latest revision as of 10:17, 21 February 2024

Mcl-1 in complex with Bim BH3 mutant I2dY

3kj0, resolution 1.70Å

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