2kgl: Difference between revisions

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{{Seed}}
[[Image:2kgl.jpg|left|200px]]


<!--
==NMR solution structure of MESD==
The line below this paragraph, containing "STRUCTURE_2kgl", creates the "Structure Box" on the page.
<StructureSection load='2kgl' size='340' side='right'caption='[[2kgl]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2kgl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KGL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kgl OCA], [https://pdbe.org/2kgl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kgl RCSB], [https://www.ebi.ac.uk/pdbsum/2kgl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kgl ProSAT]</span></td></tr>
{{STRUCTURE_2kgl|  PDB=2kgl  |  SCENE= }}
</table>
 
== Function ==
===Mesd===
[https://www.uniprot.org/uniprot/MESD_MOUSE MESD_MOUSE] Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction.<ref>PMID:12581525</ref> <ref>PMID:21397183</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==About this Structure==
Check<jmol>
2KGL is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KGL OCA].  
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kg/2kgl_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kgl ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Chen, J.]]
[[Category: Chen J]]
[[Category: Wang, J.]]
[[Category: Wang J]]
[[Category: Chaperone]]
[[Category: Lrp5/6]]
[[Category: Mesd]]
[[Category: Wnt]]
[[Category: Ywtd]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:57:38 2010''
Retrieved from "https://proteopedia.org/2kgl"