3gg5: Difference between revisions

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{{Seed}}
[[Image:3gg5.png|left|200px]]


<!--
==Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability==
The line below this paragraph, containing "STRUCTURE_3gg5", creates the "Structure Box" on the page.
<StructureSection load='3gg5' size='340' side='right'caption='[[3gg5]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3gg5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GG5 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3gg5|  PDB=3gg5 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gg5 OCA], [https://pdbe.org/3gg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gg5 RCSB], [https://www.ebi.ac.uk/pdbsum/3gg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gg5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TYSY_HUMAN TYSY_HUMAN] Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.<ref>PMID:21876188</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gg/3gg5_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gg5 ConSurf].
<div style="clear:both"></div>


===Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability===
==See Also==
 
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
 
== References ==
<!--
<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_20151707}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 20151707 is the PubMed ID number.
</StructureSection>
-->
{{ABSTRACT_PUBMED_20151707}}
 
==About this Structure==
3GG5 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GG5 OCA].
 
==Reference==
<ref group="xtra">PMID:20151707</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Thymidylate synthase]]
[[Category: Large Structures]]
[[Category: Bell, B J.]]
[[Category: Bell BJ]]
[[Category: Gibson, L M.]]
[[Category: Gibson LM]]
[[Category: Huang, X.]]
[[Category: Huang X]]
[[Category: Lebioda, L.]]
[[Category: Lebioda L]]
[[Category: Lovelace, L L.]]
[[Category: Lovelace LL]]
[[Category: Methyltransferase]]
[[Category: Nucleotide biosynthesis]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 12:28:16 2010''

Latest revision as of 09:54, 21 February 2024

Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability

3gg5, resolution 2.77Å

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