3lw3: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:3lw3.jpg|left|200px]]


<!--
==Crystal structure of HP0420-homologue from Helicobacter felis==
The line below this paragraph, containing "STRUCTURE_3lw3", creates the "Structure Box" on the page.
<StructureSection load='3lw3' size='340' side='right'caption='[[3lw3]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3lw3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_felis Helicobacter felis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LW3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lw3 OCA], [https://pdbe.org/3lw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lw3 RCSB], [https://www.ebi.ac.uk/pdbsum/3lw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lw3 ProSAT]</span></td></tr>
{{STRUCTURE_3lw3|  PDB=3lw3  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/D5MNX8_HELFE D5MNX8_HELFE]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lw3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lw3 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Helicobacter pylori infect more than half of the world's population and are considered a cause of peptic ulcer disease and gastric cancer. Recently, hypothetical gene HP0421 was identified in H. pylori as a cholesterol alpha-glucosyltransferase, which is required to synthesize cholesteryl glucosides, essential cell wall components of the bacteria. In the same gene-cluster, HP0420 was co-identified, whose function remains unknown. Here we report the crystal structure of HP0420-homolog of H. felis (HF0420) to gain insight into the function of HP0420. The crystal structure, combined with size-exclusion chromatography, reveals that HF0420 adopts a homodimeric hot-dog fold. The crystal structure suggests that HF0420 has enzymatic activity that involves a conserved histidine residue at the end of the central alpha-helix. Subsequent biochemical studies provide clues to the function of HP0420 and HF0420.


===Crystal structure of HP0420-homologue from Helicobacter felis===
Crystal structure and functional insight of HP0420-homolog from Helicobacter felis.,Piao S, Jin XL, Yun BY, Kim N, Cho HS, Fukuda M, Lee H, Ha NC Biochem Biophys Res Commun. 2010 Apr 16;394(4):940-6. Epub 2010 Mar 17. PMID:20302842<ref>PMID:20302842</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_20302842}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3lw3" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 20302842 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_20302842}}
__TOC__
 
</StructureSection>
==About this Structure==
3LW3 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Helicobacter_felis Helicobacter felis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW3 OCA].
 
==Reference==
<ref group="xtra">PMID:20302842</ref><references group="xtra"/>
[[Category: Helicobacter felis]]
[[Category: Helicobacter felis]]
[[Category: Ha, N C.]]
[[Category: Large Structures]]
[[Category: Piao, S.]]
[[Category: Ha N-C]]
[[Category: Helicobacter]]
[[Category: Piao S]]
[[Category: Hotdog-fold]]
[[Category: Structural genomic]]
[[Category: Unknown function]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr  7 10:35:26 2010''

Latest revision as of 10:09, 6 November 2024

Crystal structure of HP0420-homologue from Helicobacter felis

3lw3, resolution 1.60Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=3lw3&oldid=4257645"