1wkn: Difference between revisions

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{{Theoretical_model}}
{{Theoretical_model}}
{{Seed}}
[[Image:1wkn.png|left|200px]]


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==A PLAUSIBLE MODEL OF FULL-LENGTH INTEGRASEDNA COMPLEX==
The line below this paragraph, containing "STRUCTURE_1wkn", creates the "Structure Box" on the page.
<StructureSection load='1wkn' size='340' side='right'caption='[[1wkn]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WKN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wkn FirstGlance], [https://www.ebi.ac.uk/pdbsum/1wkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wkn ProSAT]</span></td></tr>
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</table>
{{STRUCTURE_1wkn|  PDB=1wkn  |  SCENE=  }}
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A model of the full-length HIV-1 integrase dimer was constructed assembling the experimentally determined structures of the single domains. Subsequently, the three-domain protein-viral DNA complex was generated for the first time through an automated docking algorithm, obtained modifying the ESCHER program, a well-known method for protein-protein docking. A detailed study of the contacts established with DNA by the enzyme revealed that the predicted model reproduced the results of mutagenesis and cross-linking experiments, confirming the validity of our docking approach in predicting the base specificity in the DNA-protein interaction.


===A PLAUSIBLE MODEL OF FULL-LENGTH INTEGRASEDNA COMPLEX===
Analysis of the full-length integrase-DNA complex by a modified approach for DNA docking.,De Luca L, Pedretti A, Vistoli G, Barreca ML, Villa L, Monforte P, Chimirri A Biochem Biophys Res Commun. 2003 Oct 31;310(4):1083-8. PMID:14559226<ref>PMID:14559226</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_14559226}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1wkn" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 14559226 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_14559226}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Theoretical Model]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WKN OCA].
[[Category: Large Structures]]
 
==Reference==
<ref group="xtra">PMID:14559226</ref><references group="xtra"/>
[[Category: Barreca, M L]]
[[Category: Barreca, M L]]
[[Category: Chimirri, A]]
[[Category: Chimirri, A]]
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[[Category: Villa, L]]
[[Category: Villa, L]]
[[Category: Vistoli, G]]
[[Category: Vistoli, G]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr  8 06:41:09 2010''

Latest revision as of 16:20, 27 October 2021

Theoretical Model: The protein structure described on this page was determined theoretically, and hence should be interpreted with caution.

A PLAUSIBLE MODEL OF FULL-LENGTH INTEGRASEDNA COMPLEX

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