5zna: Difference between revisions
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< | ==EVIDENCE FOR A NEW Z-TYPE LEFT-HANDED DNA HELIX: PROPERTIES OF Z(WC)-DNA== | ||
The | <StructureSection load='5zna' size='340' side='right'caption='[[5zna]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ZNA FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5zna FirstGlance], [http://www.ebi.ac.uk/pdbsum/5zna PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zna ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The structure of Z-DNA, currently accepted as a model for all left-handed DNAs, fails to provide convincing explanations for at least four well established properties of left-handed DNA polymers in solution. However, the major discrepancies between theory and experiment are resolved by the structure presently proposed for Z[WC]-DNA, a new left-handed, zig-zag double helix with Watson-Crick-type backbone directions. Structural features of Z[WC]-DNA include the presence of an additional H-bond between each guanine N2-amino group and an adjacent phosphate oxygen, the capacity to form four-stranded, base-matched complexes that should readily precipitate from solution, and backbone progressions that are the same as B-DNA (opposite to Z-DNA). However, since Z[WC]-DNA and Z-DNA have many parameters in common, they could be difficult to distinguish in a majority of existing experiments. In view of the close relationship of the new helix to B-DNA, which allows a relatively unhindered right-to-left transition in handedness, Z[WC]-DNA is theorized to be the left-handed structure preferentially generated in vivo by the torque available in naturally occurring DNA supercoils. | |||
Evidence for a new Z-type left-handed DNA helix: properties of Z(WC)-DNA.,Ansevin AT, Wang AH Nucleic Acids Res. 1990 Oct 25;18(20):6119-26. PMID:2235494<ref>PMID:2235494</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 5zna" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Z-DNA model tour|Z-DNA model tour]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | [[Category: Theoretical Model]] | ||
[[Category: Large Structures]] | |||
== | |||
< | |||
[[Category: Ansevin, A T]] | [[Category: Ansevin, A T]] | ||
[[Category: Wang, A H]] | [[Category: Wang, A H]] | ||
Latest revision as of 21:21, 28 October 2020
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EVIDENCE FOR A NEW Z-TYPE LEFT-HANDED DNA HELIX: PROPERTIES OF Z(WC)-DNA
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